The Met Office has issued a amber weather warning for heavy rain, with drivers being urged to be extra cautious.
The warning covers covers north Lancashire and Cumbria until tomorrow evening when the weather is expected to be more showery.
Forecasters are warning the heavy rain could lead to spray and difficult driving conditions.
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National Highways is advising anyone using motorways and major A roads in the north west to drive to conditions and take extra precautions in heavy rain such as cutting their speed, driving with dipped headlights and keeping their distance from other vehicles, leaving extra room for braking.
A spokesperson from National Highways said: "National Highways' around-the-clock regional operations centre near Warrington and its operational control centre at Penrith will be closely monitoring conditions along sections of its roads like M6 and A66.
"National Highways traffic officers and maintenance teams at depots across Lancashire and Cumbria will be on standby tonight and tomorrow to respond to any rain-related incidents."
Drivers are also being advised to pay attention to messages on overhead electronic signs.
Full advice, including precautions for driving in heavy rain and the measures National Highways will be taking to manage any incidents is included on a dedicated webpage at: https://highwaysengland.co.uk/road-safety/travelling-in-severe-weather/travelling-when-it-s-raining/
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