The USGS has announced the powerful earthquake was of a magnitude 6.7. Other affected countries include parts of Syria, Georgia, and Armenia.
The epicentre of the earthquake has been confirmed to have occurred in Doğanyol, Malatya, Turkey.
Seismologists believe the quake originated 6 miles (10km) under the ground.
No reports of casualties or damage has yet been reported.
The quake is believed to have struck at 8.55pm local time (5.55pm GMT).
Distressing but as-yet unverified video shows collapsed houses.
Emergency sevices are seen already at the scene, while volunteers scramble looking for victims amongst rubble.
A USGS statement on their site reads: "Earthquakes of 6.1 to 6.9 magnitude may cause a lot of damage in very populated areas."
Although the quake has now passed, locals can expect aftershocks hours, days, or weeks after the main quake.
Aftershocks can cause building damage and falling debris that could injure you.
Sitting 2,116 m (6,942 ft) above sea level, the Turkish town of Doğanyol is thought to be home to approximatelhy 6,500 people.
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