Traffic has "clogged up" the main road through South Cave after a crash nearby.
Humberside Police said officers had closed the A1034 Kettlethorpe Hill at its junction with the B1230, around a kilometre north of South Cave, following the collision.
Motorists were advised to avoid the area, with many being turned around or diverted along West End and Church Street in South Cave.
A spokesperson for Humberside Police said on Twitter at just after 1pm: "Road closures are in place on the A1034 Kettlethorpe Hill [junction] with the B1230 to allow emergency services to deal with a road traffic collision.
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"Please avoid the area if possible."
Traffic information site Inrix said in an update at 1.45pm that the accident was causing heavy traffic and was affecting the roads between Newbald and South Cave.
It is believed the road is closed in both directions with no through access to traffic while emergency services deal with the incident.
Any updates on this ongoing incident will appear below.