Manchester United travel to Anfield on Sunday to face off against Premier League juggernauts Liverpool in the clash of the weekend.
Despite being the only team to take points away from Jurgen Klopp’s men, the Red Devils have a tough battle ahead of them.
Marcus Rashford’s availability is up in the air due to a back injury sustained midweek, and Ole Gunnar Solskjaer has already suggested the striker will play no part against their old rivals.
United's neighbours Man City will be keeping an eye on proceedings as they bid to keep pace with Liverpool.
They host a Crystal Palace side looking to climb into the Europa League spots, but an away fixture against the defending champions is no easy task.
After picking up just six points in their last five games, Leicester will be hoping to get back on track as they travel up north to take on 15th-placed Burnley .
The Clarets are also desperate to turn things around, having lost their last four fixtures.
Making up the top four, Chelsea have a comfortable five-point lead over Man Utd, and will be seeking to strengthen their position against Newcastle on Saturday.
The Magpies have been boosted by the return of Matt Ritchie and Jamaal Lascelles from injuries, with both players in contention for a role against the Blues.
Sheffield United have a chance to gain ground on Man Utd, but make the trip to the Emirates to face a resurgent Arsenal .
The Gunners are without their top goal scorer Pierre-Emerick Aubameyang for the clash, so will have to muster up some fire power elsewhere to get the better of the Blades - who beat them in the return fixture back in October.
After being knocked out of the FA Cup, Wolves can now turn their attentions back to the Premier League.
But an away fixture against Southampton is in store for them, who boast an in-form Danny Ings among their ranks, who has netted five goals in his last five league games.
One of those goals proved to be the winner against Tottenham , who have only earned five out of a possible 15 points in their last five games.
Spurs are looking to reignite their top four hopes against 17th-placed Watford , who are currently one of the in-form sides in the division.
Carlo Ancelotti will be urging his side to build on their win over Brighton last weekend when they visit West Ham.
In the opposite dugout, David Moyes faces off against his old club, with the Hammers teetering above the relegation zone and desperate for results.
All three teams in the drop zone are also in action, as Aston Villa make the journey to the south coast to play Brighton , while there's a big relegation clash between Bournemouth and Norwich at the vitality stadium.
Here's how Sav see the weekend's action panning out...
Robbie Savage's Premier League predictions
Watford 2-1 Spurs
Arsenal 1-1 Sheff Utd
Brighton 1-0 Aston Villa
Man City 3-1 Crystal Palace
Norwich 0-1 Bournemouth
Southampton 2-1 Wolves
West Ham 2-1 Everton
Newcastle 0-2 Chelsea
Burnley 0-2 Leicester
Liverpool 3-0 Man Utd