A street in Collyhurst was sealed off by police after officers received reports of a firearm.
Five cars were also damaged with a brick during a disturbance on Burgin Walk shortly after midnight on Saturday morning.
Police say a firearm was reported but 'no evidence' of a gun had since been found.
Thornton Street North nearby was sealed off for most of Saturday.
No one has been arrested.
A spokesperson for Greater Manchester Police said: "Police were called shortly after midnight on Saturday 15 May to a report of a disturbance near an address on Burgin Walk, Manchester.
"Enquiries are ongoing after a firearm is said to have been seen, but no evidence has yet corroborated this.
"Around five vehicles were damaged with a brick but no injuries were reported.
"No arrests have been made."
Anyone with information should call 101 quoting incident 8 of 15/05/2021. Details can be passed anonymously to the independent charity Crimestoppers on 0800 555 111.