Cardiff and Swansea will go into local lockdown from 6pm on Sunday, the Welsh Government has confirmed.
Under the restrictions, people will not be able to enter or leave the areas without a reasonable excuse.
They will not be able to meet indoors with anyone they do not live with, with extended households suspended.
People must work from home when possible, health minister Vaughan Gething told a press conference in Cardiff.
The town of Llanelli will go into local lockdown on Saturday at 6pm.
This is a breaking news story – more to follow