A man was chased by a gang of thugs in Jeeps before his hand was seriously wounded with a machete.
The 21-year-old was chased down the street by people in a number of vehicles, police have said.
He was rushed to hospital following the attack on Chirkdale Street, Kirkdale, just before 6pm on Monday.
Reports from the scene last night suggested the man's hand had been "chopped off," but police confirmed today that this was not the case.
However, the 21-year-old did sustain a very serious hand injury and he is set to undergo surgery to repair a significant wound.
The injury has been described as a "life-changing."
This morning, detectives launched a fresh appeal for information to help catch those responsible as forensic, CCTV and witness enquiries are ongoing.
Detective Inspector Gary Thomas, of Merseyside Police, said: “We are doing all we can to find who was responsible for this violent attack so we can put them before the courts.
“I would urge anyone who was in the area of Chirkdale Street, Goodall Street and Delamore Street last night who saw anything or anyone suspicious to come forward as any information you hold could be vital to our investigation.
“Similarly, if you were in the area and captured any mobile phone or dashcam footage then please let us know, either directly or through Crimestoppers.
"However you choose to get information to us, rest assured, we will take action to identify those responsible.”
Photos from the scene showed a badly damaged car and car parts scattered all over.
The attack was one of three very serious knife incidents in Merseyside yesterday following the murder of a man, in his 20s, in Huyton, and the stabbing of a 15-year-old boy in Childwall.
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You can pass information via police's social media desk via Twitter @MerPolCC or Facebook ‘Merseyside Police Contact Centre’, or call 101 with reference 21000249256.
You can also contact the independent charity Crimestoppers anonymously, on 0800 555 111 or via their online form at: https://crimestoppers-uk.org/give-information/give-information.