Police, fire and the ambulance services are responding to a 'serious' crash at Simister Island roundabout on the border of Manchester and Bury.
Highways England says the M60 is currently closed clockwise between Junction 18 and Junction 17.
In a tweet, the agency said: "The #M62 on the roundabout itself at #J18 ( #SimisterIsland#M60#M66 ) is currently CLOSED due to a serious collision.
"Traffic Officers @[email protected] & @manchesterfire are currently at the scene.
In update, the agency added: "The #M60 clockwise #J17 ( #Whitefield#Prestwich#A56 ) to #J18 ( #SimisterIsland#M62#M66 ) is currently CLOSED due to a serious collision."
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