Captain Scott McMann believes there can be "no excuses" for a poor showing against Kilmarnock despite missing eight players.
Three players who had tested positive on Monday are now shown to be negative for coronavirus.
The trio will remain in self-isolation for 10 days alongside defender Lee Hodson, who came into contact with St Mirren goalkeeper Jak Alnwick.
Boss Brian Rice confirmed there will be at least four players missing through injury and doesn't expect to be able to fill his bench.
However, McMann is targeting back-to-back wins after an impressive result against Livingston last weekend.
"I think most teams are going to experience things like this throughout the season," said McMann.
"We would obviously rather not be in this situation but we have to deal with it.
"We're not looking to make any excuses that we can't get a result.
"I wouldn't change the rules, I don't know the ins and outs of it, but as long as everyone is safe while playing I don't see why we can't."
It is expected that Accies will bring untested players into the first-team this weekend
"There is definitely more players ready to come through," he added. "It's the same every season.
"There is always new boys coming through, getting their chance and staying in the team. No doubt more can come in and do that this season."
The skipper reckons the New Douglas Park outfit are at their best when they are the underdogs.
"We never give in and never know when we are beat, and hopefully we can keep sneaking results when nobody fancies us."