City haven’t witnessed a goalless first half in 15 straight Premier League matches.
So while City are a modest 2/5 with thepools.com to build on last week's victory over Arsenal, odds of 5/6 for City to win the first half are much more appealing.
No Gabriel Jesus and possibly no Kevin De Bruyne means City will rely on Sergio Aguero and Raheem Sterling for goals.
Sterling loves a goal against The Hammers with the winger scoring eight in 13 meetings against the East London club and he is evens to score anytime.
Aguero is naturally favourite to score first at 14/5 .
West Ham will be on a high after coming from 3-0 down to grab a late equaliser against Spurs last Sunday.
And The Irons will be keen to carry that momentum as they look to go four games unbeaten in the Premier League.
The pools.com is the country's oldest and longest established betting outlet.
But if you haven't got an account yet, thepools.com is offering new customers a great introductory offer!
If new customers bet £10 at odds of evens or greater, you get another £10 bet absolutely free.
You can bet on any match, any market. Simply log on to thepools.com and register for a new account - you don't need to deposit a penny.
18+, UK only. New customers only. Full T&Cs apply. Visit thepools.com for info. begambleaware.org
Manuel Lanzini scored a sensational brace and is 6/1 to find himself on the scoresheet anytime with thepools.com - 20/1 to score first too.
Elsewhere, top scorer Sebastien Haller looks set to return to the matchday squad and he's 9/1 to score first.