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WHO says Omicron is no worse than other variants and jabs should work against it

Pfizer's Covid booster jab triggers a 25-fold increase in antibody levels against Omicron, the company revealed today as it admitted two doses may not be enough to protect against infection from the mutant strain.

The vaccine-maker announced that three injections provide a 'more robust' defence against the variant, which has caused chaos since it was first identified in South Africa last month.

A third dose triggers a similar antibody response against Omicron as the response seen against previous strains of Covid after two doses. It also ‘strongly increases’ T cell levels that protect against severe disease, lab tests by the company showed. 

It comes as two other studies released today show that vaccines appear to work better than expected against the mutant variant.

A research institute in South Africa found people fully-vaccinated with Pfizer's jab make 40-times fewer antibodies against Omicron compared to other variants. But scientists behind the research, one of four new lab studies, said the results are 'better than expected'.

Another study by Swedish virologists found that while there is a drop in the body's ability to neutralise Omicron after jabs, this decline is not seen in everyone and is a smaller fall than feared.

Meanwhile, a World Health Organization official said Omicron appears to be less severe than other Covid variants.

Dr Michael Ryan, the WHO's emergencies director, said despite likely being more transmissible than other variants, early data suggests Omicron is less severe than other strains.

And vaccines should protect against severe illness and hospitalisation, as they have done for previous worrying variants, such as Beta and Delta, Dr Ryan said. 

Even if it causes milder illness than other strains, if a large proportion of the population catch the virus, it could put the NHS under severe pressure if hospitalisations trend upwards. 

But a third set of lab results from Germany found that double-jabbed people may not produce any neutralising antibodies against Omicron, and even once boosted the vaccines are 37 times less effective against the new strain than Delta.

However, it is unclear whether this reduced antibody response will have an effect on serious illness, hospitalisations and deaths, as other parts of the immune system, such as T cells, are considered key in suppressing severe outcomes. 

UK officials hope the booster rollout to all adults — which Boris Johnson pledged to deliver by the end of January — will increase protection against the strain, which experts believe will be dominant by Christmas.

The Prime Minister yesterday acknowledged Omicron appears to be more transmissible. 

Professor Neil Ferguson, an epidemiologist at Imperial College London and Government scientists, this morning said a lockdown could be imposed if the NHS is overwhelmed.

Scientists at the Karolinska Institutet in Stockholm found there was an average seven-fold drop in neutralisation potency among 17 blood donors

Researchers at the African Health Research Institute (AHRI) found the Pfizer vaccine triggers forty times fewer antibodies capable of fighting the Omicron variant compared to an older version of the virus. The graph shows that antibody levels — scientifically known as geometric mean titer (GMT) FRNT50 — among 12 people jumped to an average of 1,321 when they were exposed to an older strain of the virus (D614G). But when scientists tested their blood against Omicron, antibody levels dropped to an average of 32, marking a 41.4-fold decrease. Six of the volunteers were double-jabbed with Pfizer (orange), while the other half were double-jabbed with Pfizer and had previously tested positive for Covid. People previously infected with Covid had the most protection 

Eminent epidemiologist Professor Tim Spector claimed infections of the highly evolved variant were doubling every two days. The above graph, based on MailOnline analysis, shows how the number of daily cases of Omicron could breach the 100,000 barrier before New Year's Day, if that pace continues

No10 announced last week that it plans to ramp up the booster programme to 500,000 jabs per day and offer a third dose to all 53million British adults by the end of January to shield against the incoming wave. But the scheme already appears to be stalling with less than 330,000 delivered across Britain yesterday and just 380,000 administered each day on average. At the current rate, all eligible adults will not be boosted until February 10

Pfizer's Covid booster jab triggers a 25-fold increase in antibody levels against Omicron, the company revealed today as it admitted two doses may not be enough to protect against the mutant strain. The vaccine-maker announced that three injections provide a 'more robust' defence against the variant, which has caused chaos since it was first identified in South Africa last month. A third dose triggers a similar antibody response against Omicron as the response seen against previous strains of Covid after two doses. It also ‘strongly increases’ T cell levels that protect against severe disease, lab tests by the company showed

Michael Ryan, the WHO's emergencies director said: 'The preliminary data doesn't indicate that this is more severe. In fact, if anything, the direction is towards less severity'

WHAT DOES THE LAB EVIDENCE SHOW ABOUT VACCINE EFFECTIVENESS AGAINST OMICRON? 

1. South Africa

People vaccinated with Pfizer have 40 times less antibodies that can fight against Omicron compared to other variants, according to one lab-based study.

Researchers at the African Health Research Institute (AHRI) took blood samples from 12 people double-jabbed with Pfizer. 

They examined levels of neutralising anitbodies that can prevent infection from Omicron.

The researchers found there is a 40-fold decrease in antibodies that fight against the strain, compared to the number that can defend against other variants.

The study only looked at antibodies, which are just one part of the immune respone that fights off the virus. Although they are normally a reliable indictor. 

It is not clear that this will translate into lower protection against severe illness, hospitalisation and death among those who catch the strain. 

The researchers also found that Omicron still uses the ACE2 receptor on cells to infect people.

Professor Alex Sigal, a virologist at the AHRI who led the study, said this means the variant can be managed with the vaccines we have.

2. Sweden

A separate study by researchers in Sweden found that while there is a drop in the body's ability to neutralise Omicron it is not seen in everyone and is a smaller drop than feared.

Scientists at the Karolinska Institutet in Stockholm found there was an average seven-fold drop in neutralisation potency against Omicron.

But it varied between a 1-fold and 23-fold reduction among patients. 

Researchers said almost all blood samples evaluated had some form of neutralising antibody response against Omicron.

Their findings were based on recent blood samples from 17 people in Stockholm, compared to 17 hospital workers who were previously infected with the origianl Wuhan strain.

Benjamin Murrell, an assistant professor in computational biology, virology and immunology and one of the researchers behind the study, said this is 'certainly worse than Delta' but is not 'as extreme as we expected'. 

He said the AHRI study reported a 'much more substantial average reduction' but noted 'what is common is that neutralisation is not completely lost for all samples, which is positive'. 

3. Germany

A third set of results shared by researchers in Germany found neutralising antibodies from two doses of the vaccines used in the UK are ineffective against the strain. 

Dr Sandra Ciesek, a virologist at the German Center for Infection Research, tweeted laboratory findings, which have not yet been published, show that six months after two doses of Pfizer or Moderna, or a first dose of AstraZeneca and second dose of Pfizer, there was no neutralising antibodies present that could protect against Omicron. 

And even three months after being boosted with the Pfizer jab, people had just 25 per cent protection from neutralising antibodies against Omicron, compared to 95 per cent protection at the same point against Delta. 

Dr Ciesek said this translates into a 37-fold reduction against Omicron compared to the Delta strain. 

The findings confirm that developing new vaccines that target Omicron 'makes sense', she said.

But Dr Ciesek noted that the results 'cannot say anything' about whether people are still protected from severe illness, which other parts of the immune system play a key part in warding off.   

Pfizer’s results are based on a laboratory study using the blood of people triple-jabbed one month earlier with its vaccine, which is tested against the Omicron variant.

The results showed that the booster jab neutralised the Omicron variant ‘to levels that are comparable to those observed’ for the original Wuhan virus after two doses.

Blood samples for people who were only double-jabbed had a 25-fold reduction in their antibody levels against Omicron compared to the original strain.

This indicates two doses of the Pfizer injection ‘may not be sufficient to protect against infection with the Omicron variant’, the company admitted.  

However, despite Omicron’s extensive mutations, Pfizer believes two jabs will protect people against severe forms of disease and are monitoring its real-world effectiveness to confirm this.

But a third dose may provide a 'more robust protection' by triggering a 25-fold increase in antibody levels, it said.

Some 437 Omicron cases have been spotted in the UK since the virus was first identified in South Africa.

The Government has reintroduced mandatory face covering rules, added 11 countries to the red list and tighter restrictions for UK arrivals. 

Mr Ryan said the strain is likely more transmissible than previous variants, but is 'highly unlikely' to completely evade vaccine protections.

He said: 'The preliminary data doesn't indicate that this is more severe. In fact, if anything, the direction is towards less severity.'  

The WHO official said there was no sign that Omicron could fully sidestep protections provided by existing Covid vaccines.

'We have highly effective vaccines that have proved effective against all the variants so far, in terms of severe disease and hospitalisation... 

'There's no reason to expect that it wouldn't be so' for Omicron, he added, pointing to initial data from South Africa, where the strain was first reported.

However, Ryan acknowledged that it was possible that existing vaccines might prove less effective against Omicron, which counts more than 30 mutations on the spike protein that dots the surface of the coronavirus and allows it to invade cells.

It comes after researchers at the African Health Research Institute (AHRI) found people who received the Pfizer vaccine have 40 times less antibodies that can defend against Omicron. 

The scientists examined blood samples from 12 people double-jabbed from Pfizer — who had not yet received their booster.

The pre-print study, which is yet to be peer-reviewed, found Omicron's mutation seemed to enable it to dodge many of the vaccine-triggered antibodies. 

However, the study only looked at antibodies, which are just one part of the immune response that fights off the virus. Although they are normally a reliable indicator. 

And those most vulnerable to Covid are eligible for a third shot of vaccine, which experts hope will boost the protection compared to having just two doses. 

It is not clear whether the reduced number of antibodies will translate into lower protection against severe illness, hospitalisation and death among those who catch the strain.

Professor Alex Sigal, a virologist at the AHRI who led the study, tweeted that the results of the study are 'better than I expected of Omicron'.

He noted there is a 'very large drop' in protection from Pfizer compared to other variants, but those who previously had Covid and are vaccinated were more protected against the variant. 

Professor Daniel Altmann, an immunologist at Imperial College London, said it offers a 'clear message' that those who are unvaccinated or double-jabbed 'are likely to be highly vulnerable to infection'. 

'However, those who've seen spike three times, either by boosting or by infection plus two doses, appear generally in the safety zone, even with a 41-fold drop,' he said. 

The study provides 'an even stronger argument for getting boosters as widely and rapidly as possible', Professor Altmann said.

And Professor Penny Ward, an expert in pharmaceutical medicine at King's College London, said it is 'not surprising' that higher levels of antibodies are needed to neutralise Omicron compared to other strains due to its 'complex series of mutations'.

She noted that when scientists looked at other strains in the laboratory they found similar reductions in vaccine effectiveness, but this did not lead to a real-world drop in protection against severe illness. 

'After a year's experience with the covid vaccines, we know that lower levels of antibody, while being less effective at preventing infection, remain very highly effective at reducing hospitalisation and mortality rates,' Professor Ward added.

And Professor Jonathan Ball, a virologist at the University of Nottingham, noted that while 'the amount of virus killing observed in the lab is reduced markedly – up to 40-times reduction – there is still measurable virus neutralisation, especially in those who were vaccinated and previously infected.'

'This group effectively mimics what we would expect in people who had had two doses of vaccine plus a boost,' he said.

Professor Ball added: 'Whilst we do not fully understand what protective immunity looks like, the data should give us reassurance that the vaccine will still offer protection.

'The other thing to remember is that many of the vaccines also generate T cell immunity and we think that this will be less impacted by the high level of mutations that omicron has.

'Whilst this reduced antibody immunity might mean more people can be infected and have mild symptoms, I am still confident that the vaccines, especially after a boost, will still protect from serious disease. 

'That's why we still need to get the message across, get vaccinated, get boosted, even if you have been infected before.' 

Professor Neil Ferguson warns lockdown might be needed to stop Omicron overwhelming NHS

'Professor Lockdown ' Neil Ferguson today admitted that another nationwide shutdown could be on the cards to tackle Omicron as he warned the super variant will be dominant before Christmas.

The Government scientist, whose modelling bounced No10 into the original lockdown last spring, said the return of stay-at-home orders 'certainly might be possible' if the mutant strain threatens to overwhelm the NHS . 

He told the BBC Radio 4 Today programme: 'There is a rationale, just epidemiologically, to try and slow this down, to buy us more time principally to get boosters into people's arms because we do think people who are boosted will have the best level of protection possible, but also to buy us more time to really better characterise the threat.'

Asked outright if a lockdown could be reimposed, he said: 'Clearly if the consensus is it's highly likely that the NHS is overwhelmed then it will be for the Government to decide what to do about that but it's a difficult situation to be in of course. It certainly might be possible at the current time.' 

It is unclear how the British public would react to social restrictions over Christmas after fresh allegations surfaced this week that Boris Johnson held a rule-breaking lockdown party in Downing Street last December, when millions of Britons were unable to visit loved ones. 

And a separate study by researchers in Sweden found that while there is a drop in the body's ability to neutralise Omicron is not seen in everyone and is a smaller drop than feared.

Scientists at the Karolinska Institutet in Stockholm found there was an average seven-fold drop in neutralisation potency among 17 blood donors.

Benjamin Murrell, an assistant professor in computational biology, virology and immunology and one of the researchers behind the study, said this is 'certainly worse than Delta' but is not 'as extreme as we expected'. 

He said Professor Sigal's study reported a 'much more substantial average reduction' but noted 'what is common is that neutralisation is not completely lost for all samples, which is positive'. 

A third set of results shared by researchers in Germany found neutralising antibodies from two doses of the vaccines used in the UK are ineffective against the strain. 

Dr Sandra Ciesek, a virologist at the German Center for Infection Research, tweeted laboratory findings, which have not yet been published, show that six months after two doses of Pfizer or Moderna, or a first dose of AstraZeneca and second dose of Pfizer, there was no neutralising antibodies present that could protect against Omicron. 

And even three months after being boosted with the Pfizer jab, people had just 25 per cent protection from neutralising antibodies against Omicron, compared to 95 per cent protection at the same point against Delta. 

Dr Ciesek said this translates into a 37-fold reduction against Omicron compared to the Delta strain. 

The findings confirm that developing new vaccines that target Omicron 'makes sense', she said.

But Dr Ciesek noted that the results 'cannot say anything' about whether people are still protected from severe illness, which other parts of the immune system play a key part in warding off. 

Professor Francois Balloux, a geneticist at University College London, said results from different neutralisation studies are difficult to compare and it is too early to know why the results from the German study 'look so much worse'. 

'Whatever the reason, those results do not suggest that neutralising antibody activity can be restored by a third dose,' he said.

This is the image that has sparked fear among scientists, prompted ministers to turbocharge the UK's booster vaccine rollout and seen the return of mask mandates in England. It details the new super-mutant Omicron variant's spike protein mutations which experts fear will make it the most infectious and vaccine-resistant strain yet. The graphic, released by the country's top variant monitoring team, also lays bare how it is far more evolved than even the world-dominant Delta strain, with nearly five times as many alterations on the spike 

'Those results suggests that a large proportion of the population globally is at risk of (re-)infection by the omicron variant over the coming months,' Professor Balloux said. 

But he noted milder symptoms have so far been recorded among those infected with Omicron.

Just a FIFTH of over-50s in inner-city areas have already had a top-up vaccine 

England's Covid booster vaccine divide was laid bare today, with just over a fifth of over-50s having had their top-up jab in parts of the country.

MailOnline analysis shows some areas have already dished out third doses to 90 per cent of the most vulnerable adults, who were originally prioritised in the rollout. 

The booster programme is set to be opened up to over-40s who had their second dose three months ago from tomorrow morning, with No10 targeting Christmas shoppers with 'booster buses' to help speed up uptake. 

It has been accused of being sluggish, especially in the face of the oncoming wave of infections fuelled by the supermutant Omicron variant. Ministers have consistently said boosters are key to warding off the threat of the wave.

NHS England's most up-to-date vaccination statistics show thousands of neighbourhoods dotted across the country have already given third doses to the majority of adults.

But dozens of inner-city areas are massively lagging behind in the roll-out, according to this website's analysis of the figures. 

And real-world data suggests vaccines are still protecting against severe illness through other antibodies and T cells, Professor Balloux added.

Top US scientist Anthony Fauci echoed the WHO's view, saying Omicron did not appear worse than prior strains based on early indications - and was possibly milder.

The new variant is 'clearly highly transmissible,' very likely more so than Delta, the current dominant global strain, Fauci told AFP.

'It almost certainly is not more severe than Delta,' he added. 'There is some suggestion that it might even be less severe.'

But he noted it was important to not over-interpret this data because the populations being followed skewed young and were less likely to become hospitalised. Severe disease can also take weeks to develop.

'Then as we get more infections throughout the rest of the world, it might take longer to see what's the level of severity.' 

It comes as UK daily Covid infections jumped 15 per cent in a week to 45,691, with scientists estimating Omicron cases are doubling every two days. 

'Professor Lockdown' Neil Ferguson today admitted that another nationwide shutdown could be on the cards to tackle Omicron. 

The Government scientist, whose modelling bounced No10 into the original lockdown last spring, said the return of stay-at-home orders 'certainly might be possible' if the mutant strain threatens to overwhelm the NHS. 

He told the BBC Radio 4 Today programme: 'There is a rationale, just epidemiologically, to try and slow this down, to buy us more time principally to get boosters into people's arms because we do think people who are boosted will have the best level of protection possible, but also to buy us more time to really better characterise the threat.'

Asked outright if a lockdown could be reimposed, he said: 'Clearly if the consensus is it's highly likely that the NHS is overwhelmed then it will be for the Government to decide what to do about that but it's a difficult situation to be in of course. It certainly might be possible at the current time.'

Only 8% of hospitalised Covid patients in South Africa's Omicron ground zero now get admitted to ICU which is just a THIRD of level seen during Delta wave, fuelling hopes that the super-mutant variant IS milder

ByLuke Andrews Health Reporter For Mailonline

Intensive care rates among hospitalised Covid patients in South Africa are now running at just a third of the level they were at the same point in the country's Delta wave, official figures suggest amid hopes Omicron has evolved to be milder. 

In Gauteng province, the super-mutant variant's 'ground zero', 139 Covid patients in hospital were being cared for in intensive care wards on Monday, about two weeks into the nation's latest wave. This was the equivalent to 8 per cent of all infected patients who were admitted for treatment. 

For comparison, there were 393 infected patients in ICUs in the two weeks after Delta took off in the province, or 24 per cent.

Experts have warned the raw number of admissions and ICU patients could still overtake the levels seen during the Delta wave in June because of how long it takes for infections to translate into serious illness. 

But British scientists told MailOnline the promising data, from the Government's National Institute for Communicable Diseases, offered evidence that the variant could be milder than other mutant strains.

It also backed up claims from South African doctors on the frontlines who say fewer Covid-infected patients need ventilators than was the case when Delta took hold. Other real-world data from Norway and the UK also suggests the mutant strain may be less lethal than its rivals.

Some experts have speculated the virus may have evolved to become less severe over time, but others question if it is merely the result of very high levels of natural immunity in South Africa after the Delta wave.

Up to 80 per cent of South Africans are believed to have had Covid now and recent infection helps keep reinfection cases mild.

The finding offers hope that the UK's Omicron wave could be less severe than past peaks. But scientists warn the mutant strain will pile pressure on the NHS if it is more transmissible because of the sheer number of people who will catch it.

Data already suggests the mutant strain is more transmissible than Delta, and Boris Johnson yesterday told his Cabinet that 'early indications' are that it is more contagious. Its rapid spread across the UK has sparked fresh concerns that more curbs could be introduced before Christmas.  

The proportion of Covid patients hospitalised in Gauteng, South Africa's Omicron epicentre, is significantly lower during the current wave (left) than the Delta wave (right). The start of the two waves was set when South Africa announced it had detected its first case of each variant

The proportion of Covid patients hospitalised in Gauteng who were on ventilators during the Omicron and Delta waves is shown above. It also reveals that significantly fewer patients are on ventilators now than when Delta took hold. The start of the two waves was set when South Africa announced it had detected its first case of each variant

The above graphs show the Omicron and Delta waves in terms of Covid cases (far left), Covid patients in hospitals (centre) and the proportion of patients in ICU (right). The start of the two waves was set when South Africa announced it had detected its first case of each variant

No10 officials have insisted the Government will act 'swiftly' to contain the variant if necessary, and have drawn up plans to ask people in England to 'work from home'.

Top experts said cases were doubling around every two to three days and the strain would be dominant in weeks, and possibly 'before Christmas'. It has now been spotted 437 times in Britain, but that is just a fraction of the true toll.

It comes after a South African study found antibodies in 12 patients who were double-vaccinated with Pfizer had 40 times less antibodies against the mutant strain than older variants. But antibodies are just one part of the overall immune response to Covid, with B and T cells also playing a crucial role.

Pfizer vaccine provides FORTY times fewer antibodies to fight Omicron than it does other Covid variants 

The Pfizer Covid vaccine could be significantly less effective against the newly discovered Omicron variant than it was against previous strains of the virus.

Researchers at the African Health Research Institute (AHRI) found that there are forty times less antibodies in Pfizer vaccine recipients that can fight Omicron than there are for other variants.

The pre-print study, made available Tuesday pending peer-review, implies that the vaccine could be less effective against the strain detected last month in South Africa.

Conclusions from it cannot yet be drawn, though, and researchers are not yet sure how much more likely the Omicron variant is to cause infection in a vaccinated person than other strains are.

The new variant has been detected in at least 19 U.S. states and nearly 50 countries worldwide as of Tuesday night, and is feared to be the most contagious strain of the virus yet.

The AHRI research team gathered samples from 12 people who were vaccinated with the Pfizer vaccine.

None of the participants had received their booster shots yet.

Researchers analyzed the blood samples, and searched for antibodies that had the ability to prevent infection from the new mutant strain.

While the Pfizer vaccine is largely effective against other strains of Covid, including the Delta variant, the many mutations of the Omicron variant seem to be able to evade many of its antibodies.

South Africa's NICD publishes daily reports on the number of Covid patients in hospitals by provinces, and the number that are in ICU or on ventilators.

In Gauteng, where the country's largest city Johannesburg is based, the number of infected patients in hospital has jumped 65.3 per cent week-on-week.

But separate data bolstering the case that it is a milder strain suggest that just 25 per cent are being treated for the actual illness, with others just incidentally testing positive after being admitted for something else.

NICD figures showed that in the latest week — roughly a fortnight after the strain was first detected — there were 1,371 Covid-infected patients in the province's hospitals every day, on average.

Some 103 of these were in intensive care facilities (eight per cent), and 30 were hooked up to ventilators (two per cent).

For comparison, in the second week of the Delta wave there were 1,578 patients in hospital every day with 380 in the ICU (24 per cent) and 153 on ventilators (10 per cent).

But the rates now appear to be ticking up despite staying at about a third of the levels seen in the Delta wave for more than a week.

Yesterday of the 1,805 Covid patients in hospital in the region 177 were in the ICU (9.8 per cent) and 51 were on ventilators (2.8 per cent). 

The start of South Africa's Omicron and Delta waves were chosen based on when the country announced it had detected its first case of each variant. 

For Delta, this was May 8, while the first case of Omicron was announced on November 25.  

At the start of the Delta wave, the infection rate across South Africa almost doubled in a fortnight from 23.3 cases per million people to 44.2.

For comparison, when Omicron first took off daily infections surged by almost 2,000 per cent from 9.1 to 177 cases per million.

The Omicron wave kicked off when infections were at a much lower point than the Delta wave. 

The South African Government also only began to count positive lateral flow tests in its official figures from mid-November, which may have skewed the comparison.

It is not clear how many hospitalisations in the province were triggered by Omicron, but experts say it is likely to be at least the majority because the variant is now dominant in the area. 

Three of South Africa's neighbours — Zimbabwe, Namibia and Eswatini — are now seeing their cases start to rise as the variant takes hold in the region. 

For Zimbabwe, which shares a 140-mile border with South Africa, its infection rate has risen more than 700 per cent in a week from 5.22 cases per million people to 45.6.

In total, there are 46,000 Covid cases on average each day in the UK and data from the Covid Genomics UK Consortium (COG-UK) suggests the new strain is already behind around one in 66 of them, or 1.4 per cent

In Namibia infections are also up more than 700 per cent from 4.1 to 34 cases per million people. And in Eswatini,   a tiny nation landlocked by South Africa and Mozambique, the infection rate has rocketed 1,300 per cent from 11 to 154 cases per million.

Genomic sequencing in the countries is poor, meaning it is not clear how much Omicron is to blame for their outbreaks. But experts have said it was likely to be responsible for the uptick in all three of the countries. 

All 120 partygoers who caught Omicron super-strain from ONE PERSON at Norwegian Xmas work night out have MILD symptoms 

None of the 100-plus partygoers who caught Omicron at a Norwegian Christmas party believed to be the world's biggest coronavirus super-spreader event have fallen seriously unwell.

Doctors involved in tracing the outbreak say the infected are so far only suffering very mild symptoms like fevers, coughs, headaches and tiredness following the festive do on November 26.

Some 120 people who attended the Louise Restaurant and Bar in Oslo have tested positive for Covid, all of which are suspected to be Omicron but only 13 have been confirmed in a lab.

Seventy of the infected were employees of solar power company Scatec, who were celebrating their Christmas work night out, while the remaining 50 were other guests at the restaurant. The party was held in a closed room but guests reportedly mingled with other people in the restaurant after 10:30pm, when it turned into a nightclub.

'Patient zero' is thought to be a Scatec staffer who had recently returned from the company's head office in Cape Town, where the variant is already dominant nationally. They tested positive the day after the party. At least one other employee had also recently returned from a trip to South Africa.

The Oslo outbreak made international headlines and was the first warning sign to Europe that the highly-evolved variant was viciously virulent and could outpace Delta on the continent.

But Dr Tine Ravlo, a public health expert in the Norwegian capital involved in tracking the outbreak, said that so far 'none have become severely ill and none of them have been treated in hospital'.

The development lends weight to the theory that Omicron might be weaker than past variants, and is consistent with reports from doctors in ground zero of the outbreak in South Africa.

Norway's state epidemiologist, Frode Forland, told The Telegraph that if this turns out to be true, it could signal the beginning of the end of the pandemic.

'That is the hope. That is the best scenario we can have,' he said. 'That it's getting minder, most people will get it, and they will get a natural immunity.'

Scientists have long predicted the coronavirus is unlikely to ever be eradicated but will instead transition into a milder cold-like virus as the world develops stronger immunity. 

Professor Francois Balloux, a geneticist at University College London, said it was possible that the variant is less virulent than first feared based on the figures.

He told MailOnline: 'Hospitalisations may indeed be lower than during earlier waves because a larger proportion of the population in South Africa has now acquired immunity through prior infection and/or vaccination or because Omicron itself is less virulent than Delta, or a bit of both.

'This view is solely based on Gauteng data so far.'

Professor Paul Hunter, an infectious diseases expert at the University of East Anglia, agreed that it was possible the mutant strain could be less virulent than Delta.

'It is quite possible,' he told MailOnline. 'But what I would say is you often don't end up on ventilators until two or three weeks after infection. 

'So it is still too early to be definite, but there are early signs in the data that this may be the case.'

He added that at a WHO meeting this week, data was revealed that showed patients in all age groups were about a third as likely to suffer severe disease as those who caught Delta.

But again, many are still facing a relatively early illness which could get worse over time. 

Professor Hunter warned even if it was less virulent the fact it is more transmissible means it could still lead to as many hospitalisations as Delta.

He said: 'If there is a 50 per cent reduction in virulence but it is four times more transmissible, then you get double the number of people severely ill.' 

Dr Jeffrey Barrett, who heads up variant sequencing at one of Britain's largest surveillance centres, at the Sanger Institute, said the figures could be down to higher immunity levels now than when Delta first spread.

He told MailOnline: 'If people with prior infection had no immunity to infection from Omicron, but high immunity from hospitalisation, then in a country like South Africa you'd see exactly what we're seeing now.

'Lots of infections, including reinfections, but a lower proportion of severe disease.'

He added: 'We need to see carefully matched datasets comparing Delta and Omicron hospitalisation conditional on vaccine status, prior infection, age, and so on. That will probably happen in three to four weeks time.'

Some 24 per cent of people in the country are vaccinated against Covid, but most are already thought to have some immunity against the virus from previous infection.

A study carried out in February found half of almost 5,000 people tested had Covid antibodies. Since then the country has been hit by the more transmissible Delta wave.

Some scientists have suggested that the virus may become less virulent over time as it adapts to living in humans.

Dr Tine Ravlo, a public health expert in the Norwegian capital involved in tracking the outbreak, said that so far 'none have become severely ill and none of them have been treated in hospital'. 

But critics of the theory, which has circulated ever since Alpha was detected last year, warn there is no evidence that this will happen and that it could in fact become more dangerous. 

South African doctors say they have noticed a 'high number' of Covid patients that are on 'room air', rather than being hooked up to ventilators.

Covid cases are also starting to rise sharply in three of South Africa's neighbours as the Omicron variant takes hold in the region. These are Eswatini — which is landlocked between South Africa and Mozambique —, and Namibia and Zimbabwe which both share more than 50-mile borders with the country

Dr Fareed Abdullah, an infectious disease doctor at Steve Biko hospital in Gauteng, told the Financial Times: 'You walked into a Covid ward any time in the past 18 months... you could hear the oxygen whooshing out of the wall sockets, you could hear the ventilators beeping.

'But now the vast majority of patients are like any other ward.'

South Africa's Covid cases yesterday tripled week-on-week after another 13,147 infections were recorded, and hospitalisations more than doubled with another 383 admissions reported.

In Britain 437 Omicron cases have been detected to date. But there are yet to be any hospitalisations or deaths associated with the mutant strain.

It comes after top epidemiologist Professor Spector claimed the highly evolved variant was already taking hold in Britain.

The King's College London scientist, who runs the country's largest symptom-tracking study, estimated that in 10 days' time Britain will have more Omicron cases than most African countries at the epicentre of the new outbreak, meaning there would be 'very little point' in having travel restrictions.

No10 yesterday warned the variant is now spreading domestically in multiple regions, with the official count now standing at 336 although none of those infected with it have been hospitalised. Separate data shows the strain is thought to make up one in 60 of all new cases.

Dominic Raab today claimed that ministers were not looking to bring in tougher Christmas curbs, working from home or vaccine passports, despite the sharp uptick in Omicron. 'We don't think Plan B is required,' he told BBC Radio 4's Today programme. 'Why? Because of the success of the vaccine programme.'

Mr Raab was more definitive than Boris Johnson who yesterday refused to rule out tightening restrictions over the festive period, merely insisting that Christmas will be 'better' than last year.

Scientists expect booster jabs to give high protection against severe illness and death from Omicron, even if the variant makes vaccines much less effective at preventing infection. 

Is the Omicron variant more dangerous than earlier strains and will my Covid-19 vaccines still protect me if I decide to have a quick snog under the mistletoe? 

Some people seem very worried about the new variant. Should I be, too?

Intense research into Omicron has only just begun, so it's too soon to know much for certain.

So far there has been a lot of speculation 'which isn't helpful', said Dr Julian Tang, a virus expert at the University of Leicester. 'Relatively little is known about Omicron, even among scientists,' added Professor Mark Woolhouse, an epidemiologist at the University of Edinburgh.

The facts so far are as follows. On November 25, South African health officials announced an uptick in Covid cases linked to a new variant. Due to the large number and type of mutations, or changes, to the variant, it could be more transmissible, the scientists said – meaning it could spread faster than previous iterations.

The next day, the World Health Organisation (WHO) declared it a variant of concern, and named it Omicron – the 15th letter in the Greek alphabet – following its variant naming system.

Since then it has been identified in more than 20 countries worldwide, including Britain.

Last Thursday, Dr Michelle Groome of South Africa's National Institute For Communicable Diseases said there had been an 'exponential increase' in infections over the past two weeks. In mid-November, the country – where just a quarter of the population have been jabbed – was seeing roughly 300 new cases per day.

Last Monday they recorded 2,858 cases. By Wednesday it was 8,561, and on Friday it was 16,055.

Based on what's being seen there, experts say the South African scientists' initial assessment seems correct – Omicron is likely more infectious than the currently dominant Delta variant, which itself was 60 per cent more infectious than the Alpha variant which overtook the original Wuhan virus in late 2020.

And it is this, primarily, that has caused concern. 

How much more infectious is Omicron?

However, due to South Africa's low vaccination rate it's not possible to make direct comparisons with European countries.

'We'd need to see more numbers before putting a figure on it,' said Prof Woolhouse.

I have read ominous things about 'vaccine escape'. Does this mean our jabs won't protect us against Omicron?

The swift spread of Omicron in South Africa hints that it has some capacity to overcome existing immunity, but there is no suggestion that the vaccines will no longer be effective.

Indeed, scientists we spoke to believe the jabs will still provide an 'incredibly strong' protection against serious illness, which is key. And this is why the booster programme, which aims to have every adult offered a third dose by the end of January, is still vital.

What we know for certain is that a South African study published last week examined medical reports of roughly three million people with lab-confirmed Covid. It found 35,670 suspected reinfections – people who'd caught Covid a second time after having tested positive three months or more before. Based on this data, the scientists estimated Omicron was three times as likely to cause reinfection as the Delta or Alpha variants.

'This is not overly surprising,' said Professor Francois Balloux, director of the Genetics Institute at University College London.

'The large number of mutations in the spike protein [is likely to] increase the Omicron variant's ability to bypass immunity.'

The spike protein is part of the Covid virus that allows it to bind to healthy cells – much like a key entering a lock. The outer shell of the roughly spherical viral particle is covered in them.

Most Covid vaccines, including the Pfizer, Moderna and AstraZeneca jabs, are designed to mimic the coronavirus spike protein. They work, in part, by teaching the immune system to create defensive cells called antibodies which recognise and attach to this part of the virus – stopping the key from ever entering the lock.

Scientists have long known that the more changes there are to the spike protein, the more likely it is that Covid antibodies, even in a fully vaccinated individual, will not recognise the virus, allowing it to slip past the body's defences. In Omicron, the spike protein has 32 mutations differentiating it from previous variants, which is what has led experts to suspect that existing antibodies will be less effective in fighting it off.

How much this is the case isn't known. This is partly because antibodies are not the only cells that the immune system develops to fight off viruses.

The Covid vaccines also trigger the creation of T-cells and B-cells – fighter cells that attack foreign invaders – and experts believe that these cells will still be able to identify the Omicron variant, neutralising it before the majority of fully vaccinated people become seriously unwell.

A similar pattern was seen with the Delta variant which arrived in the UK in March. Early lab studies suggested mutations to the spike protein would allow it to slip past many of our antibodies, and scientists estimated the jabs would be only 67 per cent effective – a massive fall from the initial 90 per cent touted by the manufacturers.

However, half a year on, experts believe protection against Delta provided by the vaccines only fell by roughly three per cent.

'We have our T-cells and B-cells to thank for this,' said virologist Dr Tang, 'and I expect we'll see the same with Omicron.

'The majority of the vaccinated population will still be protected from the worst of the disease.'

Is it true that Omicron is causing a milder illness than previous variants?

Early signs, again from South Africa, suggest that many people who catch Omicron are experiencing only mild symptoms. However, experts have warned against making too many comparisons or forecasts at this stage.

Based on the current evidence, little is known about the severity of infection – with or without vaccination – caused by Omicron. Prof Balloux said: 'South Africa has a low vaccination rate but a large proportion of the population has been infected during previous Covid-19 waves. The population of South Africa also tends to be fairly young, with a median age of 27.6 years [compared with 40 in the UK]. More data will be needed before we can make robust predictions about the potential threat posed by a global spread of Omicron.'

Speaking at a press conference on Wednesday, the WHO's Dr Maria Van Kerkhove said: 'We have seen reports of cases with Omicron that go from mild all the way to severe. There is some indication that some the patients are presenting with mild disease, but it is early days.'

The severity of Covid illness depends on a multitude of factors, which is what makes this a particularly difficult question to untangle – and a proper answer may not come for many months.

The main concern is that, even if it's not causing severe illness in general, Omicron could spread rapidly through the vaccinated population, increasing the chances that it will reach vulnerable people whose immune systems have not been sufficiently trained by the vaccines, or the unvaccinated.

Professor Penny Ward, a pharmaceutical expert at King's College London, said: 'It may be a while before we know the effect on older, more vulnerable people.'

How quickly is Omicron spreading in the UK?

Some 437 cases of the Omicron variant detected in the UK, but scientists believe there are already many more that haven't been picked up.

A cluster of cases was identified in Scotland, while individual cases have been seen in almost every region of England and in parts of Wales. None have been identified in Northern Ireland to date. 

Experts warn the actual number could be closer to 2,000 — more than four times the official count. They add that cases of the mutant strain are likely doubling every two to three days and that it could trigger a major wave by Christmas.  

'We know from experience of Alpha and Delta that by the time you've learnt it's here, the horse has already bolted,' said Dr Tang. 'Considering we have so few restrictions in place, it's likely this virus will propagate at speed.'

However, it will likely take some time before it outpaces Delta, which is still causing nearly 50,000 new cases each day. 

Will we see more restrictions?

On Monday, Health Secretary Sajid Javid confirmed that hospitalisations would be 'what matters more than anything' when considering further measures. And based on what we know so far, these are unlikely to rise for some time.

The variant would have to significantly reduce the effectiveness of the vaccines before major social restrictions such as lockdowns were necessary in the UK, experts told us.

But Whitehall officials are already drawing up plans for work from home in England, while people have been told to start following the policy if they live in Scotland.

No10 has called on businesses not to cancel their Christmas parties, but many companies are already doing this. 

Studies show the booster jabs, which have now been given to nearly 90 per cent of Britons over the age of 70, provide an unprecedented level of protection against the virus – and even if Omicron 'dents' this, we're starting from an ideal position to fight it off, said Dr David Strain, clinical Covid lead at the Royal Devon and Exeter NHS Foundation Trust.

The effect of this is already being seen in the UK, where hospitalisations are now falling – particularly in older age groups – even as Covid cases rise.

Dr Strain explained: 'The boosters put us in a wonderful position before this new variant arrived. Omicron has dented that campaign somewhat, but if you are fully boosted you are still in an ideal position to defend against it.'

Disease modellers believe that the strength of the boosters is such that the NHS could 'tolerate' even a large wave of Omicron.

Prof Woolhouse said: 'Healthcare settings could probably bear some fall-off in protection, given just how effective the boosters appear to be.

'However, I'd like to see some numbers before I say that with certainty. Studies looking at how effective the boosters are against this variant are a priority right now.'

On November 25, the Government announced that it would temporarily ban travellers from six southern African countries, and reintroduce PCR tests for all passengers on arrival, no matter where from, to combat the spread of the variant.

And last week masks once again became mandatory in indoor public spaces, including shops and public transport.

These measures will buy the UK some time while scientists race to analyse the variant, ministers have said.

We've been told that boosters are vital – but the rules keep changing. How will I know when and where to get mine?

Last week the Government announced that all adults would be offered a booster Covid vaccine three months after their second dose. It means the entire adult population will have at least been given the opportunity to have a third dose by the end of January.

On Friday, NHS England issued an update, saying the rollout would begin on December 13.

Until then, those eligible to book a booster remains as it was: only those aged 40 and over; those aged 16 and over with a health condition that puts them at high risk from Covid; and frontline health and social care workers who had their second dose more than six months ago.

These groups should already have received an invitation, via text message or email or both.

After December 13, as with the initial vaccine campaign, people will be invited in descending age order. Again, this will be in the form of text or email.

At present, if you look at the NHS Covid vaccine booking website, it states in a yellow box at the top of the page: 'The NHS is working on plans to offer a booster dose to everyone aged 18 years old and over... Please wait to be contacted by the NHS.'

The Government recommends that people book a jab appointment or locate a walk-in service through the NHS website (go to nhs.uk, scroll down and click 'Find out about Covid-19 vaccination' – or Google 'book a Covid jab', and click on the top result, titled: Book or manage a coronavirus (COVID-19) vaccination).

The process is relatively straightforward and requires people to enter their name, age, and address (the nhs.uk booking form asks if you know your NHS number, however it's not a problem if you don't have this to hand).

Once this is done, you will be given a list of nearby clinics where you can access the booster. These might be a GP surgery, a pharmacist, a hub at a community centre, hospital or a walk-in service.

Anyone who has trouble accessing the internet can book their booster jab through their GP, but family doctors have asked that this is done as a last resort.

Dr Dean Eggitt, a Doncaster-based GP, said: 'If you ring up your surgery for help with a booster jab, they should be able to organise it for you, but you could be waiting on the phone for quite some time so it is far speedier to do it online.'

Eligible people who are housebound will be prioritised under the new system, and should already be known to their GP, who will organise a booster to be done in the home. If you are housebound and are not sure if your GP is aware, you should contact them. Patients in hospital who have not yet had their booster will also be able to receive their shot in hospital.

In some areas, such as the Isle of Wight and Hampshire, special 'booster buses' have been deployed, offering jabs to eligible passers-by in different locations on each day.

Do we have enough vaccines to boost everyone?

Yes, but the real challenge will be finding enough people to administer them. According to the Government, there are enough available vaccines to offer every adult in England a top-up shot by the end of January.

To achieve this, the number of boosters administered every day will have to increase from 350,000 to 500,000.

Speaking last Tuesday, Prime Minister Boris Johnson said that 1,500 pharmacies would begin providing boosters alongside temporary vaccine centres that will be 'popping up like Christmas trees', as well as 400 military personnel and a 'jabs army' of volunteers.

GPs will also be called on to carry out more boosters, and will be offered up to £30 per vaccine given. However, GPs have warned this will affect the level of care they can offer patients.

Dr Eggitt said the challenge was enormous: 'If we're expected to vaccinate on this ambitious timeline, practices will have to make the decision over what they will do less of, and that may include measures such as temporarily suspending routine health checks.'

What about Christmas? Is it really OK to carry on as planned?

Yes, but it wouldn't hurt to be careful, say experts. It is too soon to say how quickly the Omicron variant will proliferate, but based on experience with the Delta variant it will take several months before it becomes widespread.

This means the chances of catching Omicron right now are incredibly small, and that will still be so in three weeks' time. For this reason, socialising with family is still a low-risk activity.

'I really don't think Christmas is anything to worry about,' said Professor Paul Hunter from the University of East Anglia.

'During Christmas and Boxing Day you're actually mixing with fewer people than you do on a normal day – so if anything you're reducing your chances of catching it during this period.'

Scientists point out that, right now, the huge presence of Delta is a bigger worry, with more than 50,000 new cases a day.

Ministers have sent mixed messages, with Work and Pensions Secretary Therese Coffey warning the public not to 'snog' under the mistletoe, and Mr Javid countering that 'it's got nothing to do with the Government who you kiss'.

He did however encourage people to take lateral flow tests before attending Christmas parties.

Prof Hunter said: 'I think if you are older, and concerned about your health and Omicron, I would probably recommend giving crowded Christmas parties in busy bars a miss, because the number of people you will be mixing with is much larger.

'I wouldn't tell anyone to cancel their Christmas Day plans.'

Prof Woolhouse said: 'There's nothing in the data to suggest any need for a policy change before Christmas. Hospitalisations and deaths are still falling.

'I agree that taking a lateral flow test before attending a Christmas party would be wise – we know these tests will flag up this new variant, as well as others.'

Could more jabs be needed, even after the booster?

Possibly. On Thursday it was announced that the UK had bought 114 million extra booster jabs from Pfizer and Moderna, which will be used over 2022 and 2023. Vaccine developers are already putting plans in place to adapt their current jabs to the new variant, should it be deemed dangerous, but this does not necessarily mean that new vaccines will be needed.

The technology used to create the Pfizer and Moderna jabs can be tweaked at speed to match the mutations of emerging variants. Last week Pfizer said it was investigating the Omicron variant to assess whether an 'adjustment' was needed. If it is, the American firm said it could develop new doses in six weeks and begin shipping in just over three months.

Moderna and Oxford-AstraZeneca have also said they are analysing how effective their vaccines are against Omicron. However, Ugur Sahin, chief executive and co-founder of Pfizer's German partner BioNTech, said: 'We think it's likely that vaccinated people will already have substantial protection against severe disease caused by Omicron.'

Despite this, virus expert Professor Lawrence Young, at Warwick Medical School, said it would be prudent for the manufacturers to adapt future boosters to the Omicron variant whatever the result. 'There are only so many mutations that can occur to the spike protein, and Omicron has the most we've seen yet by far. Any vaccine that can be adapted to match it will have a good chance at fighting off any future variants too.'

There seem to be more questions than answers. When will we know more?

Experts say it could be months before we have a clearer understanding of Omicron.

Scientists around the world are currently analysing the variant. Blood samples taken from people either previously infected with the virus or fully vaccinated against it will be exposed to Omicron, to see how the two interact. Primarily, they will be looking at how effective existing Covid antibodies are at neutralising the new variant. Even then, laboratory tests can only work out how much protection prior immunity provides. They do not tell us much about the severity of disease.

Professor Penny Ward, a pharmaceutical expert at King's College London, said: 'The only way we can know how many people will end up in hospital or dead as a result of the variant is through real-world data involving people.'

This means the more people who catch the virus the clearer the picture will become. Last week, Professor Wendy Barclay, a virologist at Imperial College London, said: 'It will take several weeks if not a few months before we have clearer answers.'

Will this blasted pandemic never end?

Government scientific advisers warned Ministers that Covid would be a threat to the NHS 'for at least a further five years', according to documents released on Friday.

After that, the scientists – members of the Government's virus modelling group Spi-M – said it was likely the virus would settle into a 'predictable endemic state' – where the virus continues to circulate in the population but does not threaten to overwhelm the health service.

The Government have already bought two more years' worth of vaccine supply, for annual boosters in 2022 and 2023.

'After Omicron there will be another variant, and another after that,' said Prof Woolhouse.

Scientists make the comparison with Russian Flu, a pandemic that occurred in the 1890s killing around one million people. Modern studies suggest that Russian Flu was a form of coronavirus called OC43, similar in structure to the one that causes Covid. Professor Young said: 'The Russian Flu pandemic went on for roughly four years and then petered out. I'd expect us to see a similar pattern.'

However, Prof Woolhouse did have some hope: 'The majority of deaths from Russian Flu happened in the first two years. Based on that, and the strength of our vaccines, I'm confident the worst of this pandemic is behind us.'