Asian stock markets suffered further slumps today as coronavirus fears continued to grip investors.
Japan's Nikkei 225 index fell 2.1 per cent while the Australian S&P ASX/200 and Hong Kong's Hang Seng both lost 0.8 per cent.
In South Korea, where 334 new cases of the virus were reported, the Kospi dropped 1 per cent to 2,056.76.
The losses continue a dire week on the global markets with US stocks suffering the worst two-day losing streak in two years on Monday and Tuesday.
Wall Street gained some ground early Wednesday but closed mostly lower last night.
In Europe the FTSE 100 Index in London slipped below 7,000 at one point on Wednesday before improving and closing up 0.35 per cent.
The Dax in Germany fell by 0.12 per cent, but the Cac 40 in France was up by 0.09 per cent and Italy's FTSE MIB rose 1.44 per cent.
Pedestrians in face masks outside a securities office in Tokyo, Japan, showing global stock markets plunging
Graph showing losses on Japan's Nikkei 225 index this week amid coronavirus fears
As the number of global cases soared past 81,000 and the death toll rose above 2,700, the central bank downgraded its growth estimate for 2020 to 2.1 per cent from 2.3 per cent.
It said the virus outbreak - which has now spread to every continent except Antarctica - would have a short-term impact on business activity after growth fell to its slowest in a decade last year.
The Bank of Korea kept its key policy rate unchanged, at its current record low 1.25 per cent.
The Shanghai Composite index rose 0.2 per cent while shares fell in Taiwan and most of Southeast Asia. Thailand's benchmark rose 0.4 per cent after tumbling 5.1 per cent on Wednesday following reports of newly discovered virus cases.
The losses in Asia came after US President Donald Trump told reporters late on Wednesday that he was open to spending 'whatever's appropriate' to fight the virus, after the Senate Democratic Leader Chuck Schumer of New York suggested 8.5 billion dollars instead of the requested 2.5 billion dollars.
He put Vice President Mike Pence in charge of the effort.
But health officials standing beside Mr Trump warned more infections are coming.
And shortly after Mr Trump spoke, the government announced that another person in the US was infected - someone in California who appears not to have the usual risk factors of having travelled abroad or being exposed to another patient.
Major US stock indexes gave up early gains, closing mostly lower on Wednesday and extending the market's heavy losses for the week.
'Previous crisis playbooks have all revolved around buying the dip in equities, so I wonder just how much further the fire sale will go before the market at least starts to scale in again,' Stephen Innes of AxiCorp said in a report.
Japan's Nikkei 225 index has fallen dramatically over the last month as fears over the spread of coronavirus and its impact on businesses and the economy have grown
Stock markets around the world have suffered a dire week as coronavirus cases increase
'But based on last night's price action, it does appear that any bounce in stocks is likely to be short-lived. And eventually, the markets could fall deeper as investors start to think what's the point of trying to pick the bottom in the short term.'
The future contracts for both the Dow Jones Industrial Average and the S&P 500 were down 1.5 per cent.
The S&P 500 index fell 0.4 per cent to 3,116.39. It is on track for its biggest monthly decline since May.
The Dow dropped 123.77 points, or 0.5 per cent, to 26,957.59, for a three-day loss of 2,034 points. A modest rally in technology stocks helped nudge the Nasdaq composite to a 0.2 per cent gain, to 8,980.77.
Smaller company stocks fell the most. The Russell 2000 index lost 0.5 per cent to 1,724.76.
Cruise operators continued falling amid persistent virus fears. Norwegian Cruise Line Holdings fell 7.9 per cent, Royal Caribbean Cruises dropped 8.1% and Carnival slid 7.5%.
Other companies that depend on travellers also declined. Expedia lost 7.1 per cent.
This graph shows the performance of Japan's Nikkei 225 index over the past six months
Graph showing losses on the Wall Street Dow Jones market on Monday and Tuesday - the biggest two-day losing streak for US stocks in two years - before investor confidence returned and markets rallied on Wednesday
Technology stocks eked out a modest gain. The tech sector was among the worst hit by sell-offs this week as many of the companies rely on global sales and supply chains that could be stifled by the spreading outbreak. Microsoft rose 1.2 per cent and Adobe rose 1 per cent.
Investors have been moving more money from stocks into bonds in the wake of the outbreak. Traders are concerned the global economy could slow down as the world's second-largest economy struggles to contain the outbreak.
The yield on the 10-year US Treasury was at 1.30 per cent on Thursday, down from 1.34 per cent. The yield on the three-month Treasury bill edged up to 1.51 per cent.
The inversion in the yield between the 10-year and the three-month Treasurys is a red flag for investors because it has preceded the last seven recessions.