On a night that was full of substance but short on drama, some thought they spotted a moment of tension between the President and First Lady right at the death.
But others dismissed it as a non-event, before the pair were pictured holding hands later in the evening as they arrived back at the White House.
Joe Biden (second right) waves to Donald Trump (second left) at the end of the second presidential debate on Thursday as Trump holds hands with his wife Melania (left)
The moment came at the end of the second and final debate - a more orderly affair than first, which had rapidly descended into a verbal slug-fest.
Melania and Jill Biden had made their way to the stage to greet their husbands and pose for the cameras.
Jill hugged her husband and the pair spoke for a short while, before Joe leaned over to talk with the moderator.
Meanwhile Trump and Melania also spoke, held hands for a short time, and then also spoke with the moderator before making for the exits.
It was at that point that Trump and Melania released each-other's hands, with some believing it showed a lack of warmth.
'Looks like passport love on the rocks,' another said.
A third quipped that the country song Stand By Your Man couldn't have been a big hit in Slovenia, where Melania was born.
But others dismissed the hand-holding, asking simply 'so what?' while others called it 'fake', pointing out that the pair held hands for some time before.
But others dismissed the event, pointing out that Melania held his hand for a minute
Prior to the debate, the Trumps were photographed together for the first time since testing positive for COVID-19 three weeks ago.
The pair were seen walking towards supporters at Nashville International Airport ahead of the event at Belmont University.
The Trumps held hands in photos showing their return to Washington later on Thursday night.
Two days earlier, Melania was forced to suddenly cancel an appearance on the campaign trail in Pennsylvania as she still had symptoms of the virus.
Her chief of staff, Stephanie Grisham, said that Mrs Trump 'continues to feel better every day following her recovery' but had a lingering cough so had decided not to travel 'out of an abundance of caution.'
Instead, she made her first post-recovery appearance at the debate wearing a black face mask which matched her sleeveless black mid-length dress.
Jill Biden also masked up, sporting a covering with the same pattern as her floral dress.
POLL SHOWS JOE BIDEN NARROWLY WON THE FINAL PRESIDENTIAL DEBATE
Former Vice President Joe Biden was narrowly judged to have won Thursday night's final presidential debate by 42% of viewers, while 39% of viewers believe President Donald Trump came out on top, according to a new poll for DailyMail.com.
In a census-balanced OnePoll survey of over 500 people, the economy was the prevailing issue Americans wanted to hear the candidates speak about, followed by the coronavirus outbreak and healthcare.
Who do you feel won the debate?
Did the final presidential debate affect your choice of who to vote for?
Which topic was important to you to hear candidates speak about tonight?
Do allegations of corruption of Hunter Biden change what you think of his father?
A little more than half of the viewers said the debate did not affect who they will vote for, with 52% saying their mind is made up, while 38% said the debate did make an impact on their preferred candidate and 12% were undecided.
The Hunter Biden corruption scandal loomed over the debate, with 48% saying the allegations against Biden's youngest son did not impact their opinion of his father. But 39% said it had changed what they think of the former Vice President.
An overwhelming 64% thought muting the microphones was effective after the trainwreck first debate saw the candidates constantly interrupting one another.
The same 64% voted that they would like to see microphones muted for all future debates.
How effectively do you feel the final presidential debate was moderated?
Do you feel the muting of microphones (for candidates not answering in initial questioning) was effective?
Would you like to see microphone muting for all future presidential debates?
There was widespread praise for NBC's Kristen Welker who moderated the debate, with 79% of viewers saying that it was moderated well. Of that, 37% said it was moderated 'very effectively' and 42% thought 'quite effectively'.
60% of viewers agreed that the final debate restored their faith in the format of presidential debates after the first.
Overall, 47% of American viewers found Thursday night's final presidential debate informative, with 18% feeling it was very helpful, 29% saying quite helpful and 30% voting that it was 'neither helpful or unhelpful'.
What region do you live in?
The majority of voters in the poll were white Democrats between the ages of 25-34.
37% of poll participants were from the South, while 22% were from the Midwest, 21% from the West and 18% from the Northeast.
The genders were evenly split in the survey, with 50.57% female and 49.43% male.
Some social media users praised the women's outfits, while others criticized Melania for not wearing a mask en route to the event.
The first lady was photographed without a mask on board Marine One.
Last week, Melania Trump took to the official White House website to detail her battle against Covid-19 and reveal that her son Baron had also been infected by the virus.
'Luckily he is a strong teenager and exhibited no symptoms. In one way I was glad the three of us went through this at the same time so we could take care of one another and spend time together. He has since tested negative,' she wrote.
She said her own symptoms were 'minimal' but hit her all at once, adding 'it seemed to be a roller coaster of symptoms in the days after.'
The First Lady added that she opted for vitamins and healthy food while suffering from the virus, which has no known cure.
She also thanked her doctor and his team and encouraged Americans to 'live the healthiest life they can' amid the pandemic.
Jill Biden (right in floral dress) is seen embracing her husband Democratic presidential candidate Joe Biden following the end of Thursday's debate while Melania and Donald Trump stand beside each other
Donald and Melania Trump arrive in Nashville, Tennessee for the second and final presidential debate ahead of the election on November 3
TRUMP AND BIDEN'S MOST MEMORABLE LINES FROM THE FINAL PRESIDENTIAL DEBATE
Trump boasts that he is 'immune' to COVID-19.
'I can tell you from personal experience that I was in the hospital. I had it. And I got better. And I will tell you that I had something that they gave me, a therapeutic, I guess they would call it, some people could say it was a cure.
'But I was in for a short period of time and I got better very fast or I wouldn't be here tonight.
'And now they say I'm immune. Whether it's four months or a lifetime, nobody has been able to say that, but I'm immune.'
Trump emphatically claims he is the 'least racist person in the room' despite calling Black Lives Matter a 'symbol of hate'.
'I have criminal justice reform done, and prison reform, and opportunities, I took care of Black colleges and universities. I don't know what to say. They could say anything.
It makes me sad. I am the least racist person. I can't even see the audience, because it is so dark, but I don't care who's in the audience, I'm the least race in person in this room.
Trump tells Biden he only ran for president because he and Obama failed.
'Joe, I ran because of you. I ran because of Barack Obama. Because you did a poor job. If I thought you did a good job, I would have never run. '
Trump accuses Biden of taking money from China and Ukraine.
'I don't make money from China, you do. I don't make money from Ukraine, you do.'
Trump says Americans can't lock themselves 'in a basement like Joe' while speaking out against another lockdown.
'We cannot lock ourselves up in a basement like Joe does. He has the ability to lock himself up. I don't know, he's obviously made a lot of money someplace, but he has this thing about living in a basement. People can't do that.'
Biden sarcastically calls Trump 'Abraham Lincoln' after the president claimed he was the 'least racist person in the room'.
'Abraham Lincoln here is one of the most racist presidents we've had in modern history. He pours fuel on every single racist fire. This guy has a dog whistle as big as a foghorn'.
Biden calls Trump 'very confused' over his plans to ax Obamacare.
'He's a very confused guy. He thinks he's running against someone else. He's running against Joe Biden. I beat all those other people because I disagreed with them.'
Biden slams Trump's cozy relationship with 'thug' Kim Jong Un.
'He's legitimized North Korea. he's talked about his good buddy - who's a thug, a thug - and he talks about how we're better off, and they have much more capable missiles able to reach US territory, much more easily than ever before.'
Biden dismisses Trump's claim that the coronavirus 'is going away'.
'He says we're learning to live with it. People are learning to die with it.'
'If you hear nothing else I say tonight, hear this … anyone that's responsible for that many deaths should not remain president of the United States of America.'
Biden announces he will 'transition from the oil industry' in favor of renewable energy.
'I would transition from the oil industry, yes … because the oil industry pollutes significantly. It has to be replaced by renewable energy over time. '