Man City have the chance to advance to the semi-finals of the Carabao Cup for the third successive season when they travel to Oxford United on Wednesday, as they look to retain the trophy once again.
The fixture against the League One side offers Pep Guardiola the opportunity to once again rest some of his key players through an intense festive fixture list.
City have faced Manchester United and Arsenal in their two previous Premier League games and have an equally tough match against Leicester City on Saturday, who sit above them in the table.
Oxford have improved massively since City won 3-0 at the Kassam Stadium in the third round of the competition last season and were on a remarkable 18-game unbeaten run (aside from a penalty loss in the EFL Trophy) before they were finally defeated 1-0 by MK Dons at the weekend.
Their route to facing City in the quarters has been equally impressive with victories over Peterborough, the Championship's Millwall, Premier League side West Ham and Sunderland.
Guardiola is no doubt aware of their brilliant season and won't be taking The Us lightly, but a much changed XI is still expected.
It would see cup 'keeper Claudio Bravo come into the side in order to rest Ederson and there will likely be a whole new defence in-front of him.
Joao Cancelo is below Kyle Walker in the pecking order at the moment so the Portuguese will likely start here to get game time under his belt and the opposite flank could see Aleks Zinchenko make his first start since returning from injury.
The heart of the defence could see the partnership of Taylor Harwood-Bellis and Eric Garcia renewed, after they performed so well together against Preston North End earlier in the competition.
Phil Foden will likely keep his place in the midfield three after being substituted after just 55 minutes in his first Premier League start of the season against Arsenal.
Ilkay Gundogan could switch to the defensive midfield role in order to give Rodri some time off and the Spaniard could be replaced with Bernardo Silva, who didn't start on Sunday.
The forward line will likely be more familiar with Riyad Mahrez coming and Gabriel Jesus keeping his place.
Sergio Aguero returned to training this week but it might be foolish to risk him so soon, especially against lower league opposition.
That leaves a slot free on the left of the attack which could be filled by Ian Carlo Poveda, the youngster trained with the first team this week but hasn't featured so far this season.
The winger played in the competition last season and may get another opportunity here.
Predicted Man City XI vs Oxford: Bravo; Cancelo, Harwood-Bellis, Garcia, Zinchenko; Bernardo, Gundogan, Foden; Mahrez, Jesus, Poveda.
Predicted substitutes: Carson, Walker, Otamendi, Angelino, Doyle, De Bruyne, Sterling.