The Ukrainian was initially slated to meet the Briton in May, but the coronavius pandemic forced the fight to be rearranged.
Usyk is risking his status as the WBO’s mandatory challenger for Anthony Joshua’s world heavyweight title, a highly-lucrative fight.
Chisora was last in action last October when he stopped David Price in four rounds, while Usyk's only action in the sport's top division was also more than a year ago against Chazz Witherspoon, with victory coming as a result of the American retiring after seven rounds.
Here’s everything you need to know about the fight.
The fight is on Saturday, 31 October, at Wembley Arena in London, coverage of the card begins at 7pm.
The exact start time for the fight is notoriously difficult to predict, but we can expect the ring walks some time after 10pm, though the outcome of the fights on the undercard will play a factor in exactly when the first bell rings.
You do not need to be a Sky customer to purchase the fight, just sign up for a Sky Sports Box Office account and purchase the fight here. Ensure you have a working broadband connection. The fight can then be streamed live on PC, Mac, NOW TV Box, NOW TV Smart Stick, iPhone, iPad, Android phone and tablet.
Repeats are at 11pm on Sunday 1 November and 9am on Monday 2 November.
Main event - heavyweight: Oleksandr Usyk (17-0) vs Derek Chisora (32-9)
Lightweight: Lee Selby (28-2) vs George Kambosos Jnr (18-0)
Cruiserweight (vacant EBU European cruiserweight title): Tommy McCarthy (16-2) vs Bilal Laggoune (25-1-2)
Middleweight (vacant World Boxing Organisation world female middleweight title): Savannah Marshall (8-0) vs Hannah Rankin (9-4)
Super bantamweight (vacant Commonwealth (British Empire) female super bantamweight title): Amy Timlin (4-0) vs Carly Skelly (3-0)
Heavyweight: David Allen (18-5-2) vs Christopher Lovejoy (19-0)
Bantamweight: Ukashir Farooq (13-1) vs Martin Tecuapetla (15-12-4)
Chisora by KO/TKO: 11 / 2
Chisora by decision: 16/1