A former nursing home in Urmston became engulfed by flames.
Firefighters were called to the blaze at Shawe House Nursing Home, on Pennybridge Lane, just before 11.45pm on Monday (February 4).
Residents in the area said they smelled smoke and called 999.
Seven fire engines were initially called to the fire, which measured around 50m by 50m.
The operation has since been scaled back to two pumps and a turntable ladder.
Firefighters remain at the scene this morning dampening down flames and any remaining pockets of fire.
There are no reports of any injuries.
A number of roads surrounding the building were closed while firefighters tackled the blaze.
An investigation into the cause of the fire has been launched.
A spokesman for Greater Manchester Fire and Rescue Service said: "We were called at 11.43pm to Pennybridge Lane.
"Seven fire engines attended, a turntable unit, command support unit and the air unit.
"It was a fire involving a derelict nursing home measuring 50m by 50m.
"We have used six main jets, five breathing apparatus and a hose reel.
"We are still there."
He added: "We are scaling back to two pumps and a turn table.
"There are still pockets of fire, we are dampening the flames.
"An investigation is ongoing."
Station Manager Jon Hill said: "Our firefighters have worked hard through the night to get this incident under control.
"We have now largely scaled back and crews continue to damp down at the scene.
"We have now lifted all of the road closures that were in place so there should be no disruption to traffic this morning."
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