Two young children died after being hit by a car while playing mini-golf with their parents.

A vehicle ran into a golf course in Panama City, Florida, hitting and killing a four-year-old boy and six-year-old girl, police said.

The incident happened at around 3.30pm on Friday, according to WTVM.

Panama City Beach officials said a pick-up left the road and crashed into the golf course, striking the two children.

Emergency services at the scene of the crash

One of the kids died at the scene and the other passed away at Ascension Sacred Heart Bay Hospital, the Panama City News Herald reports.

It is not clear what caused the driver to crash into the golf course.

The incident happened on Friday

The eastbound lanes of Front Beach Road were blocked off after the incident, officers confirmed. 

Police said an investigation is being carried out by the traffic homicide unit to identify the cause of the crash, according to WJHG.

Debbie Ward, public information officer at city of Panama City Beach, said charges were pending.

She added the family were visiting from outside the state when the incident happened.

Ms Ward confirmed the two parents and their children had come from Kentucky.

Panama City Beach Police Department said it will release more information once it becomes available.