In a contest that will have a big say in the Premier League top-four battle, Spurs know that a victory will put them level on points with the Blues and send them into the Champions League places on goal difference.
Mourinho has given Spurs a new lease of life since replacing Mauricio Pochettino, with Dele Alli enjoying a rich return to form, and the midfielder’s record of five goals in four games against Chelsea will mark him out once more as one to watch.
But the prize on offer for Chelsea is to put six points between themselves and Spurs, which would go a long way to putting them clear of the chasing pack for the foreseeable future.
Here’s what you need to know.
When is the match?
Tottenham vs Chelsea takes place on Sunday 22 December.
What time does it start?
The match kicks off at 4.30pm GMT.
Is it on TV?
The game will be shown live on Sky Sports Main Event and Sky Sports Premier League from 4pm. The game can also be watched online on the Sky Go app.
Can I stream the match online?
Yes, as long as you have a Sky Go log-in and subscription.
What are the predicted line-ups?
Possible Tottenham line-up: Gazzaniga; Aurier, Sanchez, Alderweireld, Vertonghen; Dier, Sissoko; Lucas, Alli, Son; Kane.
Possible Chelsea line-up: Kepa; James, Rudiger, Zouma, Azpilicueta; Kante; Kovacic, Jorginho; Willian, Abraham, Pulisic.
What are the odds?
Tottenham to win: 7/5
Chelsea to win: 21/10
What is our prediction?
Tottenham are the form team going into the match with four wins from their last five, and with Chelsea wobbling of late and the wily Mourinho set to show his young apprentice how it’s done, we’re backing a home win.
Tottenham 2-0 Chelsea