Hull and many East Yorkshire towns and villages could be completely submerged by water in less than 30 years.
A map, published by Climate Central, shows that the majority of East Yorkshire - including the whole of the city of Hull - could be below the annual flood level by the year 2050.
The map for 2050 shows that along with Hull, Hedon, Thorngumbald, Withernsea, Hornsea, Howden, Goole, Brough, North Ferriby and Barton are all at risk.
Parts of Hessle, Cottingham and Beverley could also be affected.
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The report is based on global-scale datasets for elevation, tides, and coastal flood likelihoods.
In 2019, the report found the UK to be among the top 20 countries most likely to be impacted by subsequent surging sea levels if global temperatures continued to rise as predicted.
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That was the conclusion of analysis using machine learning, a form of artificial intelligence, of an 'improved' global elevation dataset.
At the time, Dr Scott Kulp and Dr Benjamin Strauss, senior computational scientist and chief scientist respectively at US-based climate change research group Climate Central, were published in a peer-reviewed paper in the scientific journal 'Nature Communications'.
They said in the report: "As humanity pollutes the atmosphere with greenhouse gases, the planet warms.
"And as it does so, ice sheets and glaciers melt and warming sea water expands, increasing the volume of the world's oceans.
"The consequences range from near-term increases in coastal flooding that can damage infrastructure and crops to the permanent displacement of coastal communities."
They said current projections of sea level increases by the end of the century range from 2ft to 7ft, but could change depending on how much more pollution is dumped into the atmosphere and how quickly the world's glaciers destablilize.
But understanding the effect of that rise in sea levels is incomplete without knowing the relative elevation of land levels.
The authors said much of this data was either unavailable or too expensive to be publicly accessible, so they developed their own computer model to collect the data themselves.