Just before heading to a commercial break, Jack quipped: "Taylor Swift will be receiving her Global Icon BRIT Award.
"Imagine how amazing it would be if she gave her little statue to Kanye."
The comment caused chaos on Twitter with some of Taylor's fans absolutely disgusted by what they heard.
One commented: "A KANYE JOKE.... IN 2021..... jack whitehall has to go #brits2021"
Another wrote: "I'm so sick of Kanye jokes.. It's not 2009. Grow up! #brits2021 @taylorswift13"
And a third put: "The kanye joke wasnt even funny, imagine how Taylor feels hearing it #brits2021"
However, Jack did have some fans on board, with some hailing his risky joke.
Several fans took to Twitter to put laughing face emojis about the comment, with one writing: "JACK WHITEHALL YOU’VE LEFT ME DEAD ALL NIGHT WATCHING, “will taylor give her little statue to Kanye” stop it i cannot."
The feud between Kanye and the Bad Blood singer has been a long-running saga.
At the MTV VMAs in 2009, the Gold Digger singer interrupted Taylor as she won Best Female Video Award.
Then, after what seemed to be water under the bridge, Kanye released a song in 2016 which took aim towards Taylor.
While the rapper said he'd had the "OK" from Taylor on the lyrics, her representatives denied any knowledge.
Kanye's soon-to-be ex-wife then got involved and leaked conversations between the pair.
She wasn't the only celeb Jack took aim at during his hosting duties at the O2 Arena, though.
Former Girls Aloud singer Cheryl also was targeted for the number of times she's changed her name, while P iers Morgan's lack of a job was also in the firing line.