The 38 hospitalised politicians make up eight percent of the State Duma - the Russian parliament.
Of the 38, one is also in the intensive care unit.
According to the latest figures, 17,347 new cases were reported today with 5,224 of those in the capital, Moscow.
There were also 219 new deaths reported as the state struggles to contain the virus.
The Kremlin has now warned the virus is beginning to take hold outside of the capital as the second wave of coronavirus strikes.
Although authorities have assured the public they have the capacity to cope with the virus, the government did admit the scenario was concerning.
Federal and regional governments are now working to try and contain the outbreak.
Russia reports highest daily rise
Russia news: 38 politicians have now been hospitalised
Spokesman for the government, Dmitry Peskov said: "The situation is quite serious.
"The epidemic has stricken the regions, it has gone east of Moscow."
One local media outlet, 161.ru did report seven people had died in the city of Rostov-on-Don when oxygen supplies in the local hospital ran out.
This claim was denied by local government officials.
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Russia: Cases are beginning to spread out of the city
In Moscow, authorities have opened temporary hospitals, while businesses have been ordered to enforce 30 percent of their staff work remotely.
Temperatures checks are also conducted at metro stations.
The number of infections in the country now stands at 1,531,224 which is now the fourth highest in the world.
Only the US, Brazil and India have a higher case rate.
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