Pep Guardiola is back on enemy territory tonight, with a burning desire to burn up the Bernabeu.
But can City build on Saturday night's impressive win at Leicester at the home of Real Madrid?
We asked City reporter Joe Bray what we can expect tonight.
Win, lose or draw?
As much as Pep Guardiola will want to win at the home of his old rivals, he would probably snap your hand off for a draw to take the tie back to the Etihad.
An away goal or two would be even better, but the important thing is to have something to fight for in the second leg. Madrid won't make it easy, so a draw at a big 13/5 with thepools.com feels the most likely outcome.
Who's a good bet for first scorer?
For City, you can't look past Sergio Aguero. He lives for the big occasion and rarely needs a second chance to score. If he gets a sight of goal, he'd be favourite to score - unless it's from the penalty spot, of course! He's 10/3 to open the scoring and Evens any time , which is bigger than he usually is in the Premier League.
Who's on the naughty step (first card)?
If Gareth Bale plays, expect him to look to prey on Fernandinho's lack of pace at the back.
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The Brazilian often positions himself well to deal with quick forwards, but on the rare occasion he's out of position, he has no problem with bringing down a player who's got past him, usually earning a booking in the process.
Who's on pens?
As much as City fans would love Ederson to step up, I'd expect Sergio Aguero to brush off his penalty miss at Leicester and step up again if needed at the Bernabeu. See above ... and no, you can't get a price on Ederson to score first!
Will City keep a clean sheet?
They have two clean sheets in two games since the winter break, and the return of Aymeric Laporte is a huge boost. But Real Madrid have quality in attack, and City would prefer to score an away goal and concede, as opposed to parking the bus. Both Teams To Score is a very likely 4/7 .