Ole Gunnar Solskjaer has recalled Scott McTominay and Fred to the Manchester United side to face Atalanta due to the energy they can offer in midfield.
United are in a poor run of form with just two wins in their previous seven games in all competitions and they were beaten 4-2 by Leicester City on Saturday.
After that game Solskjaer said something would have to give in his team but the biggest name to be dropped is Paul Pogba, with a return to the more trusted partnership of McTominay and Fred.
Atalanta are a free-flowing and free-scoring side and Solskjaer knows United will be tested tonight, but he has also planned for his side to exploit the gaps that could be left by Gian Piero Gasperini's side.
â€œI think the whole pitch is going to be pivotal, we need to cover a lot of ground, they're a very aggressive, high-intensity team," Solskjaer told MUTV.
Manchester United enjoyed a sensational transfer window, securing the signing of Cristiano Ronaldo, but Ole Gunnar Solskjaer is now under pressure to deliver silverware after a patchy start to the season. United face some big games after the international break.
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"We want to have forwards exploiting the space they give away, there are many different ways we can set up but we decided to start with Marcus as well."
Solskjaer has made three changes in total from the side that were beaten at Leicester at the weekend, with Fred, Scott McTominay and Rashford in for Nemanja Matic, Pogba and Jadon Sancho.
On Rashford, who scored as a sub at the King Power Stadium, Solskjaer said: â€œHeâ€™s worked really hard, physically his base is really good, now itâ€™s about getting minutes on the pitch and getting the match rhythm and sharpness. Hopefully, we can give him more minutes today and letâ€™s see where we go."
United are third in their Champions League group having beaten Villarreal at Old Trafford in their last game. They were poor that night and needed a 95th-minute winner from Cristiano Ronaldo to secure all three points.
Solskjaer knows the Old Trafford faithful can play a part tonight despite the scrutiny currently on his side.
â€œItâ€™s a big game, we spoke to the players about it, we know we will have them [the fans] behind us, nights like this they always turn up," he said.
"The players will turn up as well, we want to start off on the front foot to get the crowd going, if we struggle I know they will back the team."