One student has died and five have been injured after a deadly hit-and-run outside a high school, according to reports.

A suspect is in custody following the incident outside Moore High School in Oklahoma on Monday afternoon.

The vehicle involved is understood to have been a red pick-up truck, with photos having been released from the scene.

Five students have been rushed to hospital with three in a critical condition, it has been reported.

They are understood to have been members of the school's cross country team out on a training run.

One student has died and five others have been rushed to hospital after a hit-and-run outside Moore High School, according to reports

In a post on Facebook, Oklahoma's News 4 reporter Joleen Chaney said four of the students were sent to OU Medical Center.

She said two girls are "being treated for broken bones" and "one of them is unstable" while a third has a "serious head injury".

It is understood a 56-year-old male was arrested, with police awaiting a warrant to draw blood to test his blood alcohol level.

The male driver of a red pick-up truck has been arrested, according to reports

Dustin Horstkoetter, a director with the school district, said at a press conference: "We got special people that live and go to school here in Moore. And to see kids and coaches giving first aid and helping their classmates and their students … we live [in] a good community."

Moore Police Department are urging people to avoid the area “as emergency crews will be entering and exiting”.

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US Representative for Oklahoma's 4th congressional district Tom Cole tweeted he is "stunned and saddened" following the death.

"I am stunned and deeply saddened by the tragedy that occurred today at Moore High School," he posted. "My most sincere and heartfelt prayers are with the families, friends and loved ones of those who are hurting."