The first patients have been admitted to the new NHS Nightingale Hospital set up in just nine days amid the coronavirus pandemic.
A spokesperson for the site confirmed the news at the ExCeL Centre in east London which has added 4,000 critical care beds.
The hospital will mainly treat younger Covid-19 sufferers, with similar plans in the works for cities across the UK, including Glasgow.
More than 400 contractors are working alongside nearly 150 clinicians and operational staff to establish the new NHS Louisa Jordan.
It is being built at the Scottish Events Campus (SEC) in Glasgow to help deal with the outbreak.
An NHS Nightingale London spokeswoman said: "Our first patients have now been admitted to the NHS Nightingale London, as planned.
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"There is also treatment capacity available in other hospitals across London to complement the care being provided at the London Nightingale."
The London hospital was officially opened by Prince Charles from the Balmoral estate in Aberdeenshire where he had been self-isolating after testing positive for the virus.
The Prince of Wales said it "offers us an intensely practical message of hope for those who will need it most at this time of national suffering".
296 people have now died from coronavirus in Scotland - an increase of 74 deaths overnight.
The number of confirmed cases has risen to 4,229 up 268 from Monday.
A total of 199 Scots are in intensive care receiving treatment, it has been confirmed.
Of the confirmed positive cases, 1751 people are in hospital which is an increase of 152.
The UK death toll currently sits at 6,159 after an overnight rise of 786.