Newcastle United's game against Aston Villa has been called off after a significant rise in COVID-19 cases at the Magpies' training ground.
The club's training facility at Benton has been temporarily closed after a number of players and staff members tested positive for the virus in recent days.
Steve Bruce confirmed last week that three individuals, including a first-teamer who would have played at Crystal Palace, were self-isolating. That number rose to five over the weekend and has increased further in recent days.
With Newcastle unable to train, the Magpies lodged an appeal to the top-flight to postpone Friday's trip to Villa Park and the club have confirmed that the Premier League board have approved that request.
For the first time since top-flight football restarted last summer, a Premier League fixture has been called off because of coronavirus.
The black-and-whites were keen to thank Aston Villa for their 'understanding' and the game will now be rescheduled and a new date and time confirmed in due course.
'Newcastle United was one of the first clubs in the country to close its training ground prior to the first national lockdown in March and the club introduced comprehensive Covid-19 protocols in line with Premier League and government guidance to protect its players and staff ahead of Project Restart,' a club statement read.
'While the club has continued to ensure strict adherence to these protocols, and despite previously experiencing only a very small number of isolated Covid-19 cases, positive test results have risen sharply in recent days.
'Accordingly, the club is now is working with Public Health England North East (PHE), local health authorities and the Premier League in line with Covid-19 protocols to identify the source of the outbreak and to ensure the risk of further transmission continues to be minimised.
'All players and training ground staff will be re-tested this week and a meeting between the club, Premier League and PHE will take place to assess the test results.
'The club will not be naming individuals who have contracted Covid-19 and asks that their privacy is respected.'