Responding to Oprah's question, "How do you feel about the Palace hearing you speak your truth today?"
Meghan replied: "I don't know how they could expect that, after all of this time, we would still just be silent if there is an active role that The Firm is playing in perpetuating falsehoods about us.
"And, if that comes with risk of losing things, I mean, I … there is a lot that has been lost already."
Responding to the reports in The Times, a Sussex spokesman said: "The duchess is saddened by this latest attack on her character, particularly as someone who has been the target of bullying herself and is deeply committed to supporting those who have experienced pain and trauma.
"She is determined to continue her work building compassion around the world and will keep striving to set an example for doing what is right and doing what is good."