Ole Gunnar Solskjaer has confirmed that left-back Alex Telles will miss the opening exchanges of the Premier League season after sustaining an ankle injury.
The Brazilian is thought to have picked up the knock while away at the club's pre-season training camp in Surrey, from which he returned home early and subsequently missed Saturday's friendly defeat at QPR.
The United boss had initially revealed Telles would only be 'out for a few weeks', but has since given the bleak update that the full-back will actually sit out the first three games of the new season.
Speaking to United's official website, Solskjaer said: "Unfortunately, it's worse news on Alex Telles than we hoped for.
"His ankle injury is a little bit more severe than we hoped and he'll be out for a little spell at least, the whole of August I would think."
This means United will be without Telles for the curtain raiser against Leeds on August 14, before missing back-to-back away trips against Southampton and Wolves respectively.
Given first choice left-back Luke Shaw will also miss those ties as he is enjoying an extended break following his Euro 2020 heroics with England, Telles' absence presents a problem for the Red Devils.
Telles is not the only crocked United star that could miss the start of the season, with Anthony Martial still nursing a knee injury he picked up in May.
United are likely to be without Marcus Rashford, who is thought to have aggravated a persistent shoulder injury while away with England at the European Championships.
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Solskjaer gave an update on the forward, revealing: "Of course, he [Rashford] went away just to reflect on it a little bit. We have to take the best course of action for him and the club. We're still addressing that with the experts."
This comes following reports Rashford is considering discussing the idea of surgery on the knock with the United hierarchy.
It is likely United will be reluctant to grant him his wish, given the fact that if the England international were to undergo surgery on his shoulder he could miss as much as the opening three months of the season.
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