It's a quick turnaround for Ole Gunnar Solskjaer's men after Thursday's Europa League draw in Belgium.
And a very different type of challenge facing them after the trip to Bruges.
We asked our Old Trafford expert Dominc Booth what we can expect from United in Sunday's showdown.
Win, lose or draw?
Having been soundly beaten by Watford earlier in the season and considering their up and down record against teams lower down in the Premier League, this is no guarantee for United.
But you sense Solskjaer's side, at Old Trafford, will find a way of grinding out the three points — even if it's not pretty. They are odds on to win at 6/10 with thepools.com and should take victory.
Who's a good bet for first scorer?
Anthony Martial has already scored two goals this week for United and with Marcus Rashford still sidelined, you wouldn't bet against the Frenchman to take his tally to three in three and bag the opener. He's 3/1 to net first and 19/20 to score at any time .
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Who's on the naughty step (first card)?
If Scott McTominay is considered fit enough to start, as has been hinted by Solskjaer, then he should be back into the rough and tumble - and tends to pick up the odd booking.
Who's on pens?
Martial will have renewed confidence after his goals versus Chelsea and Brugge and should step up if United are awarded a spot kick.
Will United keep a clean sheet?
United have kept clean sheets in their previous two league games - and six in nine, in all competitions - so should complete a shut-out again versus the league's joint-lowest scorers. Both Teams To Score 'No' is a very generous looking 5/6 with thepools.com .