November is very early for a must-win match.
But Chelsea are on a winning six-match Premier League roll and Manchester City lost last time out to title rivals Liverpool.
Pep's men can ill afford to allow Liverpool to open up even more of a gap at the top of the table, but can they bounce back?
We asked our Manchester City expert Simon Bajkowski for his views.
Win, lose or draw?
City to win. And 4/9 with thepools.com are better odds than you'll usually see for a City home win. Certainly worth including in your weekend acca.
Who's a good bet for first scorer?
Sergio Aguero is usually good for a goal against Chelsea. To be fair, he's usually good for a goal against most Premier League opponents. He's 3/1 to open the scoring and actually odds-on, at 8/11 , to score at any time in the match.
Who's on the naughty step?
Who's on pens?
Aguero. Which makes those first scorer odds even more tempting.
Will City keep a clean sheet?
Even if Ederson is back, City's vulnerability at the back could be exposed by a potent Chelsea attack and you'd expect both teams to score. That's a short-priced 8/15 but Both Teams To Score and Either Team To Win to win is an altogether more appealing 21/20 tip.