However, United will be hoping to go six points clear with a win at Anfield as they try to inflict a first home defeat on Liverpool in the league since April 2017.
Ole Gunnar Solskjaer’s side are unbeaten in their last 15 away league games since losing to the Reds almost a year ago.
Here’s everything you need to know about the match:
The match is live on Sky Sports Premier League, with coverage starting from 4pm GMT.
Jurgen Klopp will assess Joel Matip prior to kick-off, with Nat Phillips and Rhys Williams waiting in the wings should the Cameroonian defender miss out. Naby Keita is still out with a muscle problem.
Ole Gunnar Solskjaer will use Saturday’s training session to see which players are fit to play, with Anthony Martial suffering a light hamstring issue against Burnley. Brandon Williams and Phil Jones are out.
Liverpool: Alisson, Alexander-Arnold, Fabinho, CB, Robertson, Henderson, Thiago, Wijnaldum, Salah, Firmino, Mane
Manchester United: de Gea, Wan-Bissaka, Lindelof, Maguire, Bailly, Shaw, McTominay, Pogba, Fernandes, Rashford, Cavani
Manchester United: 13/5
This is the biggest Premier League fixture of the season so far, and it could go either way – one moment of brilliance by any of the individual superstars could win the game for their respective club. However, I think it could be quite scrappy as neither side wants to lose, and they settle for a draw. 1-1.