Burnley have recalled Dwight McNeil to the starting XI while Charlie Taylor returns from injury.
It means Johann Berg Gudmundsson and Erik Pieters drop out of the side while Ashley Barnes and Chris Wood continue up front.
Jay Rodriguez and Matej Vydra are among the subs while Robbie Brady is set to play on the right of midfield.
Burnley have lost their last two top flight games 1-0 and begin the day one place and four points above the relegation zone.
The Clarets were the only side to prevent Liverpool winning a league game last season and will hope for another positive result tonight.
Liverpool are without Mo Salah and Roberto Firminio.
Burnley: Pope, Taylor, Mee, Tarkowski, Lowton; Brady, Westwood, Brownhill, McNeil; Barnes, Wood.
Subs: Peacock-Farrell, Pieters, Long, Bardsley, Cork, Gudmundsson, Stephens, Vydra, Rodriguez.
Liverpool: Alisson, Alexander Arnold, Matip, Fabinho, Robertson;Thiago, Wijnaldum, Oxlade-Chamberlain, Mane, Origi, Shaqiri.
Subs: Kelleher, Milner, Firmino, Salah, Jones, Minamino, Tsimikas, Phillips, Williams