Liverpool and Spain midfielder Thiago Alcantara hopes that the squad's Covid-19 vaccination won't have any side effects ahead of their group opener against Sweden.
Prior to the tournament, a positive test from Sergio Busquets caused the whole of the squad to self-isolate meaning the U21s would play Lithuania in the final warm-up fixture ahead of Euro 2020.
In the aftermath of the 4-0 friendly win, Leeds United defender Diego Llorente also returned a positive test.
Six players were drafted in and began training as part of a "parallel" bubble, Kepa Arrizabalaga was among those added into the squad.
Diogo Jota's Portugal teammate Joao Cancelo who was forced to pull out of the squad following his positive test and was replaced by former-Manchester United defender Diogo Dalot.
Thiago played alongside Busquets in their first warm-up match during the goalless draw with Portugal, he was part of the pre-match press conference duties ahead of the Group E opener, although it doesn't suggest whether the 30-year-old will be featuring for Spain.
"I appreciate that the vaccination is a sensitive subject," said Thiago.
"We're meant to talk about football, but these sensitive topics come up and we need to address them.
"It's gone well, we've been privileged and the government has decided to get us vaccinated.
"Obviously, that raises questions regarding the competition, about the short-term effects it might cause.
"We've got vaccinated now given a certain situation even though we have a game in three days, we need to accept it and just understand the short-term effects that it might have.
"It's been great news for us all and we just hope we don't feel any side effects ahead of the game."
The Liverpool midfielder was named on the bench for Spain's opening group game against Sweden.