Grovehill Road has been closed both ways from Cherry Tree Lane to Coltman Avenue.
Emergency services are understood to be at the scene, including paramedics and police, and drivers are being urged to avoid the area.
One woman said she drove past and saw the "really bad crash".
Traffic is likely to be delayed due to the crash as we enter rush hour.
Humberside Police have been approached for a comment by Hull Live.
We will be bringing the latest from the scene, which will appear in the live blog below.
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'Really bad crash'
One woman said: “Really bad crash on Grovehill Road near the bike shop. That bend is really bad. Hope you’re all ok.”
Road closed in both directions
Traffic system Inrix says: “Grovehill Road in both directions closed due to accident from Cherry Tree Lane to Coltman Avenue.”