Liverpool are back in action just days after putting Manchester United to the sword, with a short away trip to face Preston North End.
Victory at Deepdale would send the Reds into the quarter-finals of the Carabao Cup, and manager Jurgen Klopp could give minutes to some of the players who sat out Sunday's win at Old Trafford.
Liverpool rung the changes in the third round and still eased past Norwich City with a 3-0 victory, and Klopp may well feel his squad players have the quality to get the job done.
There's even the possibility of an entirely new starting XI, with some academy talents pushing for involvement, though the manager's options will be slightly limited by a growing injury list.
In goal, Klopp's decision may be made for him with Caoimhin Kelleher suffering from illness.
The Irishman looked up to the task when handed a Premier League start at Watford, but his place on the bench at Old Trafford was taken by Adrian.
With Alisson expected to earn a rest, Adrian is the more likely starter with doubts over whether Kelleher will have recovered in time.Read More
Liverpool don't get too many opportunities to hand their full-backs a breather, but this could be one of those chances.
Kostas Tsimikas picked up an assist in the last round, having shown at the start of the season that he has the determination to step into Andy Robertson's shoes when needed, while Neco Williams could earn a first start of the season after coming off the bench in wins against Watford and Atletico Madrid.
Ibrahima Konate gave a good account of himself at Old Trafford on Sunday, and may end up reprising the partnership with Joe Gomez which kept Norwich at bay last month.
With James Milner and Naby Keita joining Thiago Alcantara and Harvey Elliott on the treatment table, the midfield options are scarce.
Liverpool expect the game to come too soon for Fabinho, which means Curtis Jones and Alex Oxlade-Chamberlain will likely be the senior presences at Deepdale.
The third midfield spot could go to youngster Tyler Morton, who played 45 minutes in the last round and was left out of Liverpool's under-23 squad for Monday's game against Blackburn Rovers.
Image:AFP via Getty Images)
Kaide Gordon made his first Reds start in the last round, but the forward has only just returned to training and isn't expected to be ready for this game.
The other two members of the front three at Carrow Road will hope to feature again, with Takumi Minamino and Divock Origi both scoring that night but struggling for minutes since.
Liverpool may be tempted to hand the final spot in the front three to Sadio Mane, who will be fresher than some other first-teamers after only playing 15 minutes on Sunday.
"We know that we need in our game freshness and we need unpredictability, we need creativity," Liverpool assistant manager Pepijn Lijnders said.
"We know that fatigue stops that.
"If you want a team who shows hunger, who shows the will to put their game into place, to be dominant and control the game in that way, then it’s important to use the squad."
Preston will be without a number of players for Wednesday's game, with Josh Murphy, Izzy Brown, Ched Evans and Connor Wickham ruled out.
However, Liverpool loanee Sepp van den Berg has been given permission to play by his parent club, and could feature at the back.
Van den Berg agreed a second loan spell at Preston over the summer, having spent the second half of last season at Deepdale, and scored his first goal for the club in the second round of the Carabao Cup.Read More Read More