Manchester United will not have Anthony Martial or Paul Pogba to select in their side to face Leicester today (3pm kick off).
Add in injuries to Luke Shaw, Diogo Dalot and Eric Bailly — and the possible absences of Aaron Wan-Bissaka and Jesse Lingard — and the Reds could be paper-thin in certain areas for the clash.
Ole Gunnar Solskjaer has made minimal changes to his side so far this season, but this game certainly looks to be one of the Norwegian's toughest challenges of the season so far.
But what team should he pick? MEN Sport's United writers have their say...
By the time you read this, the squad might be out and Aaron Wan-Bissaka might not be at The Lowry. If he is not fit enough then it has to be Ashley Young at right-back and a baptism of fire for Brandon Williams on the left.
United are like the Argo option in midfield: There are only bad options. Nemanja Matic has looked past it for some time and Fred has not made a squad all season or played since April 24. He is still the best bad idea United have.
Mason Greenwood has to start, regardless of whether Jesse Lingard is fit. Juan Mata has to start, ditto Daniel James. Martial's absence reprieves Marcus Rashford.
Solskjaer isn't exactly blessed with options because of the injury crisis, but if Wan-Bissaka is anything close to being fit then I think United have to risk him. They simply don't possess the depth full-back, with Dalot's injury, to cope without the former Crystal Palace youngster.
Midfield will be the Norwegian's biggest problem with Pogba out injured and Fred seemingly frozen out. But I would use this game as the perfect opportunity to bring back the Brazilian alongside Scott McTominay, with Juan Mata playing in the No.10 role.
The front line virtually picks itself, with Mason Greenwood deserving of a chance to finally start a game. With him and Daniel James cutting in from the flanks, the Reds will have a chance when they break on Leicester — who are an attacking team who will leave holes at the back for United to exploit.
United might be in the middle of an injury crisis so early in the season, but facing a side like Leicester might be exactly what they need after struggling against sides they were favourites to beat.
Expectations are low, and if Solskjaer sets up well on the counter-attack then a upset might well be on the crards. Wan-Bissaka would be a massive boost at full-back, but in the worst case it'll have to be a combination of Young and Rojo at full back. Neither are particularly exciting, but both looked solid enough in pre-season.
Pogba's injury surely has to open the door to Fred, while McTominay should be tasked with the deeper role on the right. Lingard might be unpopular at the moment, but if fit would bring much needed energy to the side. The front three picks itself, but Chong and Gomes need to be on the bench.
The season is barely a month old but United's resources are already being stretched to the limit.
Wan-Bissaka is a doubt but if he is passed fit then the back four picks itself.
United's midfield was always going to look weak if Pogba sustained an injury. Matic is out of favour but he is a more sensible choice than both Pereira and Fred, the latter of whom has not made a matchday squad all season.
With Martial out, Rashford is the obvious choice at No.9 despite his obvious deficiencies in that position.
Greenwood should be handed his second start for the club.
Pick your team below: