The jurors in Harvey Weinstein's rape trial are deadlocked on the two most serious charges the producer is facing.

In a note sent to the judge during their lunch break, jurors asked if the verdict could be hung on two counts of predatory sexual assault while reaching a unanimous verdict on other charges.

Those charges carry a maximum penalty of life in prison.

After consulting with prosecutors and Weinstein's lawyers, Judge James Burke told the jury of seven men and five women to keep working towards a unanimous verdict on all charges and sent them back to continue deliberating.

Weinstein's lawyers said they would accept a partial verdict but prosecutors said "no" and Judge Burke refused to allow it.

Harvey Weinstein arriving at court in New York
Annabella Sciorra leaves the courtroom in Manhattan Criminal Court on January 23

The jury, in its fourth day of deliberations, has been particularly focused on the key aspect of two counts of predatory sexual assault - Sopranos actress Annabella Sciorra's allegations that Weinstein raped her in the mid-1990s.

In all, Weinstein is charged with five counts stemming from the allegations of Sciorra and two other women - an aspiring actress who says he raped her in March 2013 and a former film and TV production assistant, Mimi Haleyi, who says he sexually assaulted her in March 2006.

After offering Sciorra a part in one of his productions in the early 1990s, Weinstein allegedly forced his way inside her Manhattan flat before forcing himself on her and raping her.

Mimi Haleyi says Weinstein sexually assaulted her in March 2006

Weinstein also allegedly forcibly performed oral sex on Haleyi years later in 2006

Jessica Mann accused the disgraced film producer of forcing her into oral sex and raping her in 2013.

Mann testified she met Weinstein at a party seven years ago, and he quickly took interest in her and began offering her work.

She told the court she had several meetings with him to discuss her career, but he asked her for a massage at an early meeting and forced oral sex on her at a later meeting in which she thought she'd be discussing a movie role.

Jessica Mann arrives at the Manhattan Criminal Court to testify on February 4

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Mann told the court the producer physically blocked her from leaving the room and made her undress and also accused Weinstein of urinating on her.

To convict Weinstein of a predatory sexual assault charge, jurors must agree on two things - that Weinstein raped or sexually assaulted Sciorra and that he committed one of the other charged offences

The predatory sexual assault charge requires prosecutors to show that a defendant committed a prior rape or other sex crime, but does not have the statue of limitation constraints that would bar Sciorra's allegations from consideration on their own.

Weinstein has maintained any sexual encounters were consensual.