A major motorway interchange has been closed after reports of a 'serious' road traffic collision tonight.
North West Motorway Police said there would be a 'full closure' of the interchange connecting the M62 and M60 motorways at Simister Island.
The closure has been put in force for the scene to be cleared and the carriageway made safe for other traffic after the collision.
There are also reports of an overturned vehicle and a fuel spillage.
Police urged motorists to avoid the area.
The circumstances behind the collision, and whether there are any injuries, are currently unknown.
'Multiple vehicles' are said to be involved.
The Manchester Evening News is attempting to contact Greater Manchester Police.
Traffic reports stated the collision happened on the northbound M66 motorway, which also connects to the Simister Island interchange.
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The northbound carriageway remains blocked, and there are reports of stationary, queuing traffic, from junction four of the M60 to junction three at Pilsworth Road, Hollins.
Highways England said traffic was stopped temporarily between the two junctions due to a 'serious collision'.
Traffic officers, motorway police and paramedics were at the scene.
Drivers heading to Lancashire from Manchester were asked to use the M61.
"If planning to travel, avoid the area," tweeted Highways England.
North West Motorway Police tweeted: "Patrols are on scene at an RTC on the M66. This is on the northbound.
"The scene is just been cleared and we will look to open lane three past the scene.
"If heading into Lancashire form Manchester please use the M61 until the carriageway is fully re-open.
"Scene assessed and there will be a full closure at the interchange with the M62 & M60 to allow for the scene to be cleared and made safe to use."
Highways England posted online: "The M66 in Greater Manchester is closed northbound between J4 (M60/M62) and J3 (Bury) due to a collision involving multiple vehicles.
"Emergency services are at scene working to clear debris and a fuel spillage.
"Traffic this is trapped within the closure is currently in the process of being turned.
"Road users are being diverted via local routes.
"Please allow additional time for your journey and consider alternative routes at this time."