Carlo Ancelotti has been appointed the new Everton manager – signing a four-and-a-half year deal – but Duncan Ferguson has made four changes for the Premier League home clash against Arsenal, his last game as caretaker boss.
Gylfi Sigurdsson, Fabian Delph, Lucas Digne and Djibril Sidibe all come into the side following Wednesday night's penalty shoot-out defeat at home to Leicester City in the quarter-finals of the Carabao Cup.
The Scot looks to be sticking with the 4-4-2 formation he has utilised throughout his four-match reign.
But Mason Holgate, who had been playing in central midfield, is expected to revert to centre-back alongside Yerry Mina with Michael Keane dropping to the bench.
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There are changes in both full-back positions with long-serving pair Seamus Coleman and Leighton Baines making way for French duo Sidibe and Digne respectively.
Holgate's position in midfield will be filled by Fabian Delph while Sigurdsson – who takes the captain's armband – comes in for Bernard.
The substitutes are Maarten Stekelenburg, Leighton Baines, Michael Keane, Cenk Tosun, Bernard, Seamus Coleman and Moise Kean.
Everton: Pickford, Sidibe, Holgate, Mina, Digne, Davies, Delph, Iwobi, Sigurdsson, Richarlison, Calvert-Lewin.
Subs: Baines, Kean, Keane, Tosun, Coleman, Bernard, Stekelenburg.
Arsenal: Leno, Maitland-Niles, Chambers, Luiz, Saka, Xhaka, Torreira, Nelson, Smith-Rowe, Martinelli, Aubameyang.
Subs: Martinez, Mustafi, Mavropanos, Willock, Guendouzi, Pepe, Lacazette.