The European Club Association (ECA) holds "deep concern" around the safety of players scheduled to take part in the 2022 Africa Cup of Nations.

The recent emergence of the omicron variant of Covid-19 has prompted a number of nations to reintroduce lockdown measures and tighten regulations for those entering a country.

Cameroon is scheduled to host the competition between January 9 and February 6, with a number of star players from the Premier League expected to take part.

The Reds have three key men set to feature, with Mohamed Salah, Sadio Mane and Naby Keita star players for Egypt, Senegal and Guinea respectively.

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Liverpool left the ECA when the plot to establish a European Super League was revealed last April - but returned to the fold a few months after that when the project was abandoned.

The ECA's executive board convened in Paris on Thursday and released a statement relating to a number of "critical topics".

Among them was a worry about the viability of the spectacle scheduled to take place in Cameroon.

"The Board also expressed its deep concerns around player safety and welfare ahead of the African Cup Nations and upcoming international windows in early 2022, particularly in light of the worsening public health situation and the severe challenges faced during recent international windows," they said.

"The Board agreed to engage urgently with FIFA to ensure all necessary precautions are in place to protect players and club interests as the health situation continues to deteriorate in an alarming manner."

Players joining up with their countries on international duty has already posed issues for the Premier League this season.

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Chaos reigned in September for South American players who were called up, as clubs initially refused to release them for international duty given the 10-day quarantine protocols in place.

A match between Argentina and Brazil was then abandoned as four players who represented the former were in attendance and deemed to have broken rules.

A new agreement was established in October, by which fully-vaccinated players who have quarantined at a club facility - where they can only come out of the bubble to train or play - for 10 days can travel to countries that are on the government's red list.