BEN YOUNGS will become the second man to win 100 caps for England - with Jamie George getting his half century in Rome.
Scrum-half Youngs joins Jason Leonard in becoming a centurion as he cements his status as his countries most-capped back.
Hooker George notches his 50 on a day that sees Jonny Hill win his first ever cap in the second row alongside Maro Itoje.
On the bench hooker Tom Dunn, centre Ollie Lawrence and wing Ollie Thorley are also set for their Test debuts as Eddie Jones looks to win a third Six Nations title in five years.
Jones said: “We will celebrate two major achievements in Ben Youngs and Jamie George’s cap milestones.
"It’s testimony to their skill, hard work and love of playing for England, and there is more to come from both of them. We’ve trained with good intensity this week and the squad are excited by the challenge of performing at our best against Italy.
“The team have prepared well and are looking forward to putting on an England shirt and showing what they can do."
European Cup and Premiership champion Henry Slade starts at 12 with Jonathan Joseph in the 13 shirt.
However, there is no replacement fly-half on the bench with full-back George Furbank and Slade the likely cover, should skipper Owen Farrell need to be replaced.
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England team to face Italy
- George Furbank (Northampton Saints, 2 caps)
- Anthony Watson (Bath Rugby, 43 caps)
- Jonathan Joseph (Bath Rugby, 50 caps)
- Henry Slade (Exeter Chiefs, 29 caps)
- Jonny May (Gloucester Rugby, 56 caps)
- Owen Farrell (Saracens, 83 caps)
- Ben Youngs (Leicester Tigers, 99 caps)
- Mako Vunipola (Saracens, 59 caps)
- Jamie George (Saracens, 49 caps)
- Kyle Sinckler (Bristol Bears, 35 caps)
- Maro Itoje (Saracens, 38 caps)
- Jonny Hill (Exeter Chiefs, uncapped)
- Tom Curry (Sale Sharks, 23 caps)
- Sam Underhill (Bath Rugby, 18 caps)
- Billy Vunipola (Saracens, 51 caps)
- Tom Dunn, (Bath Rugby, uncapped)
- Ellis Genge (Leicester Tigers, 18 caps)
- Will Stuart (Bath Rugby, 3 caps)
- Charlie Ewels (Bath Rugby, 15 caps)
- Ben Earl (Bristol Bears, 3 caps)
- Dan Robson (Wasps, 2 caps)
- Ollie Lawrence (Worcester Warriors, uncapped)
- Ollie Thorley (Gloucester Rugby, uncapped)
In the pack Jones has named the most-experienced eight he can.
Mako Vunipola and Kyle Sinckler pack down either side of George in the front row, with Itoje and Hill in the engine room behind them.
Billy Vunipola keeps his place at no.8 despite suffering from a lack of form, with Sam Underhill and Tom Curry, the guys dubbed the "kamikaze kids" by their boss, named as flankers.