The comedian was expected to perform on Thursday through Sunday in Austin, Texas, at Stubb's Waller Creek Amphitheater.
Those performances have been cancelled and Chappelle is now in quarantine, his representative Carla Sims told The Associated Press in a statement.
Chappelle is currently asymptomatic.
He had been performing socially-distanced shows in Ohio since June, and moved his performances to Austin during the winter, Sims said. Rapid testing for the audience and daily tests for Chappelle and his team were implemented.
Comedian Joe Rogan was scheduled to perform at the shows on Friday and Saturday.
He apologized on Instagram for the cancelled shows, saying they'd be rescheduled. People who had purchased tickets to one of the cancelled performances will be able to obtain refunds at their point of purchase.
Chappelle recently made an unexpected appearance in a couple’s wedding photos in Austin, Texas. The comedian happened to be near by when the pair were posing for their first look pictures outside a hotel. Chappelle popped out from a restaurant and photobombed a couple of the images, much to the pair’s delight.
The Associated Press contributed to this report