A man in his 50s has died after being involved in a crash with a transit van.
Emergency services rushed to Causeway Lane, Altcar, at about 8.10pm on Tuesday night to reports of a crash.
Officers said the cyclist involved is believed to have been travelling in the opposite direction at the time before he was hit by a Ford Transit Tipper.
The man was taken to Aintree Hospital but he sadly died there a short time later.
The force said the family of the man, who has not been named, are being supported by specially trained officers.
Road closures were put in place for hours until 1.30am while emergency services worked at the scene.
Sgt Steve Hardman, of the Lancashire Police Tac Ops team, is appealing for witnesses to the crash.
He said: “First and foremost we send our deepest condolences to the family and friends of the man who died.
“We are now working extremely hard to piece together exactly what occurred and we would ask anybody who saw the collision, and has not yet been spoken to by police, to make contact with us as soon as possible.
"Similarly if you have dashcam footage showing the collision, or if you saw either of the vehicles involved in the moments before it happened, please get in touch.”
Anybody with information is asked to call us on 101, quoting log number 1405 of June 2nd.