The minister, who said both of the sickened people had travelled to China, added that she expects more cases to emerge within the nation's borders.
"We have two cases," she said. "We will probably have other cases."
It comes after a woman who travelled to France from Wuhan was tracked down after claiming she took drugs to mask potential symptoms of a deadly virus at the airport, according to authorities.
Ms Yan posted on Chinese social media that she “took antipyretics and managed to pass through checks at the airport and enter French territory” after suffering from a fever and a cough.
“The Chinese ambassador received calls and emails from several Chinese citizens” about the post, and contacted the woman to tell her to phone emergency services immediately, according to a spokesperson from Beijing's embassy in Paris.