AJAX thrashed Borussia Dortmund 4-0 and Real Madrid won 5-0 at Shakhtar Donetsk on a goal-crazy night in the Champions League.
Manchester City's 5-1 triumph at Club Brugge set the tone, while Mo Salah struck twice in Liverpool's 3-2 triumph away to ten-man Atletico Madrid.
And the rest of Europe kept match with the two favourites for the Premier League title, led by Lionel Messi's matchwinning double in PSG'S 3-2 comeback success at home to RB Leipzig.
England midfielder Jude Bellingham and in-demand Erling Haaland both played the whole game for German giants Dortmund but were powerless to stop a surprise romp for Group C leaders Ajax.
Marco Reus' early own goal and Daley Blind's drive made it 2-0 inside 25 minutes.
Antony then curled home and ex-West Ham striker Sebastien Haller headed his SIXTH goal in three Champions League games for his Dutch masters.
Vinicius Junior netted on 51 and 56 minutes, including a superb solo goal, as Real looked sensational in the second half for a crushing victory at Ukrainians Shakhtar.
Only Sergiy Kryvtsov's own goal separated the sides at the interval.
But Rodrygo then hit his brace and teed up Rodrygo for Real's fourth before Karim Benzema lunged home for the stoppage-time fifth goal.
Former Manchester City frontman Edin Dzeko, Arturo Vidal and Holland centre-back Stefan de Vrij scored in Inter Milan's 3-1 home win over Sheriff Tiraspol.
But the Moldovans still remain shock leaders of Group D, albeit now level on points with Real.
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Porto stunned AC Milan 1-0 in Portugal, Columbia winger Luis Diaz pouncing midway through the second period.
That left the Italians without a point from their three Group B games - compared to nine for Liverpool and one apiece for Atletico and Porto.
Uruguay forward Sebastian Coates netted twice in the first 27 minutes as Sporting Lisbon eased home 4-1 at Besitkas for theirt first points in Group C.
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