Only goal difference separates the Clarets from the Seagulls in the formative Premier League table, but an extra goal scored and one less conceded puts Sean Dyche's men in mid table, while Graham Potter's side are just outside the relegation zone.
So Saturday's clash is significant.
But which way will it go? We asked Lancashire Live's Burnley expert, Alex James, for his verdict.
Win, lose or draw?
This could well be a tight affair but Burnley can edge it and claim a victory against a side they haven't lost to in their last seven meetings. The away win is a very big 12/5 with thepools.com. The 1-0 scoreline is 8/1 while 2-1 is 11/1.
Who's a good bet for 1st scorer?
Ashley Barnes, he has four Premier League goals already and will relish the chance to add to that against one of his former clubs. 5/1 for first scorer is a good price while he is 7/4 to score any time.
Who's on the naughty step? (first card)
James Tarkowski is one of only three Burnley players to have been carded in the opening four games
Who's on pens?
Will Burnley keep a clean sheet?
Good question, neither side has managed one since the opening day and you get the sense the wait for both might continue. Which makes Both Teams To Score at 4/5 a stand-out bet.
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