Boris Johnson will today scrap the 'back to work' message as people are encouraged to work from home if they can.
Cabinet Office minister Michael Gove said there was going to be a "shift in emphasis" on the Government's advice about working from home.
He told Sky News: "If it is possible for people to work from home then we would encourage them to do so."
Mr Gove later told BBC Breakfast people should now work from home in an effort to "restrain" social mixing.
"If people can work from home, they should," he told BBC Breakfast.
"But I stress that it's very important that those people whose jobs require them to be in a specific workplace do so."
He added that it was not a case of "revisiting the days at the beginning of our response to this virus" as "workplaces are safer", adding: "But one of the risks that we have to face is that social mixing overall contributes to the spread of the virus.
"So as much as we can restrain that as possible at this stage, the better for all of us and for public health."
Mr Johnson will address the House of Commons at 12.30pm and the nation in a TV recording at 8pm, where he is expected to lay out new coronavirus restrictions.
The Government has already confirmed all England's hospitality venues - including pubs and restaurants - must shut from 10pm every night starting on Thursday and be table service only by law.
Mr Johnson is expected to announce more measures tonight.
When asked about evidence around the 10pm hospitality curfew, Mr Gove told BBC Breakfast: "There is evidence that the longer venues stay open, the greater degree of social mixing that takes place.
"So, placing a restriction like this is something that we've already done in parts of the country where the virus has been spreading particularly fast."
He added: "I think it will make a difference, but I think that there are other steps that require to be taken as well, and the Prime Minister will be saying more to the House of Commons."