Ole Gunnar Solskjaer‘s side top Group L having won three and drawn one of their four group games so far.
Astana are yet to register a point in this year’s competition, but did prove tricky to put away during the opening round of fixtures, with a late Mason Greenwood goal securing United a 1-0 win at Old Trafford.
Solskjaer is set to rotate for this fixture, with a number of youngsters included in his travelling party.
Here is everything you need to know about the Europa League clash.
With the busy festive schedule fast approaching and progression out of the group stages already secured, Ole Gunnar Solskjaer is set to rotate his squad. Both David De Gea and Sergio Romero have not travelled, which means Lee Grant is in line for a first start in goal.
Ten of the travelling squad are in line for a first team debut in Kazakhstan, with young centre-half Teden Mengi set for a starting berth. Luke Shaw may return at left-back after recovering from injury.
Manchester United: Grant, Laird, Bernard, Tuanzebe, Shaw, Garner, Levitt, Chong, Lingard, Gomes, Greenwood.
When is it?
Kick-off at the Astana Arena is 3.50pm GMT on November 28.
How can I watch it?
The match will be shown live on BT Sport 2, with coverage beginning at 3.30pm.
BT Sport customers can watch the match via the BT Sport app or on the online player.
Manchester United 19/20
A young Manchester United side may find it tough going against Astana, who are a better side than their Europa League record suggests. 1-1 is our prediction.