With four wins and two defeats from their last six matches in all competitions, United head into Saturday's tea-time clash as form favourites - but only narrow betting favourites.
United are 7/5 with thepools.com to win at Old Trafford, with the visitors slightly longer at 9/5. But the venue is the issue.
Each of United's two defeats this season have come at Old Trafford, the second an absolute mullering by Spurs. And Frank Lampard's men haven't lost on the road this season.
There are more reliable markets to explore.
While United were winning in Paris on Wednesday night Chelsea were keeping a rare clean sheet at home to Sevilla. Prior to that they shipped three goals at home to Southampton and with Over 2.5 goals produced in three of the last four meetings between these two clubs, Over 2.5 goals scored in all seven United matches this season and Over 2.5 in four of Chelsea's five games prior to Sevilla, Over 2.5 goals is just 8/13.
If both teams are going to score, we still fancy United to prevail. And United to win and BTTS is 14/5.
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Edinson Cavani hasn't kicked a ball for United yet, but still finds himself installed as 9/2 favourite to score the first goal and 7/5 to score at any time.
Following on from his goal for Germany in the Nations League against Switzerland, Timo Werner scored twice in Chelsea's 3-3 draw with Southampton last weekend and he is 5/1 to score first today and 6/4 any time.